Bédard Alexandra, Bernard Catherine, Meilleur Dominique, Taddeo Danielle, Pesant Caroline, Di Meglio Giuseppina, Gingras Nathalie, Thibault Isabelle, Agostino Holly, Bélanger Richard, Nadeau Pierre-Olivier, Frappier Jean-Yves, Stheneur Chantal, Dufresne Laurie, Bégin Catherine
Centre Nutrition, Santé et Société (NUTRISS), Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Université Laval, Québec, QC G1V 0A6, Canada.
École de Psychologie, Université Laval, Québec, QC G1V 0A6, Canada.
J Clin Med. 2024 Jan 29;13(3):778. doi: 10.3390/jcm13030778.
This study aimed to document recovery trajectories among adolescents with anorexia nervosa (AN) based on three markers of remission, namely changes in body weight, food restriction, and excessive exercise, and to identify predictors of these trajectories. One hundred twenty-six adolescent girls (14.7 ± 1.3 years) were recruited during initial assessment visits at specialized eating disorder (ED) programs in five University Health Centers across the province of Quebec, Canada. z-BMI and AN symptom severity (food restriction and excessive exercise) were assessed at initial assessment visits and subsequently reassessed at each quarterly follow-up over a 12-month period to identify recovery trajectories. Considering the three markers of remission, three distinct trajectories emerged: Group 1, rapid responders; Group 2, gradual responders; and Group 3, unstable responders. At initial visits, a difference between groups was found regarding the type of treatment ( = 0.01) and weight suppression ( = 0.02). Group 1 had a higher number of youths hospitalized than Group 2 and Group 3, and a greater weight suppression than Group 3. Furthermore, individuals with atypical AN were more likely to belong to Group 2 than to Group 1 and Group 3 ( < 0.0001). This study contributes to a better understanding of the heterogeneity of recovery trajectories in adolescent girls with AN.
本研究旨在根据三种缓解标志物，即体重变化、食物限制和过度运动，记录神经性厌食症（AN）青少年的康复轨迹，并确定这些轨迹的预测因素。在加拿大魁北克省五个大学健康中心的专门饮食失调（ED）项目的初次评估访视期间，招募了126名青春期女孩（14.7±1.3岁）。在初次评估访视时评估z-BMI和AN症状严重程度（食物限制和过度运动），并在随后的12个月期间每季度随访时重新评估，以确定康复轨迹。考虑到三种缓解标志物，出现了三种不同的轨迹：第1组，快速缓解者；第2组，逐渐缓解者；第3组，不稳定缓解者。在初次访视时，发现各组在治疗类型（P=0.01）和体重抑制（P=0.02）方面存在差异。第1组住院的青少年人数比第2组和第3组多，体重抑制比第3组大。此外，非典型AN患者比第1组和第3组更有可能属于第2组（P<0.0001）。本研究有助于更好地理解AN青春期女孩康复轨迹的异质性。
