Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou, People's Republic of China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, People's Republic of China.
Br J Nutr. 2023 Jun 14;129(11):1841-1847. doi: 10.1017/S0007114522002732. Epub 2022 Sep 1.
The association between dietary Cu intake and mortality risk remains uncertain. We aimed to investigate the relationship of dietary Cu intake with all-cause mortality among Chinese adults. A total of 17 310 participants from the China Health and Nutrition Survey, a national ongoing open cohort of Chinese participants, were included in the analysis. Dietary intake was measured by three consecutive 24-h dietary recalls in combination with a weighing inventory over the same 3 d. The average intakes of the 3-d dietary macronutrients and micronutrients were calculated. The study outcome was all-cause mortality. During a median follow-up of 9·0 years, 1324 (7·6 %) participants died. After adjusting for sex, age, BMI, ever alcohol drinking, ever smoking, education levels, occupations, urban or rural residents, systolic blood pressure, diastolic blood pressure and the intakes of fat, protein and carbohydrate, the association between dietary Cu intake and all-cause mortality followed a J-shape ( = 0·047). When dietary Cu intake was assessed as quartiles, compared with those in the first quartile (<1·60 mg/d), the adjusted hazard ratios for all-cause mortality were 0·87 (95 % CI (0·71, 1·07)), 0·98 (95 % CI (0·79, 1·21)) and 1·49 (95 % CI (1·19, 1·86)), respectively, in participants in the second (1·60-<1·83 mg/d), third (1·83-<2·09 mg/d) and fourth (≥2·09 mg/d) quartiles. A series of subgroup analyses and sensitivity analyses showed similar results. Overall, our findings emphasised the importance of maintaining optimal dietary Cu intake levels for prevention of premature death.
膳食铜摄入量与死亡风险之间的关系尚不确定。本研究旨在探讨中国成年人膳食铜摄入量与全因死亡率之间的关系。该研究共纳入了来自中国健康与营养调查（China Health and Nutrition Survey）的 17310 名参与者，这是一项全国性的中国参与者开放性队列研究。膳食摄入量通过连续 3 天的 3 次 24 小时膳食回忆和相同 3 天的称重记录来测量。平均 3 天的宏量营养素和微量营养素摄入量。研究结果为全因死亡率。在中位随访 9.0 年期间，有 1324 名（7.6%）参与者死亡。在校正了性别、年龄、BMI、是否饮酒、是否吸烟、教育水平、职业、城乡居民、收缩压、舒张压以及脂肪、蛋白质和碳水化合物的摄入量后，膳食铜摄入量与全因死亡率之间呈 J 型关系（ = 0.047）。当膳食铜摄入量被评估为四分位数时，与第一四分位数（<1.60 mg/d）相比，全因死亡率的调整后危险比分别为 0.87（95%CI（0.71,1.07））、0.98（95%CI（0.79,1.21））和 1.49（95%CI（1.19,1.86）），分别在第二（1.60-<1.83 mg/d）、第三（1.83-<2.09 mg/d）和第四（≥2.09 mg/d）四分位数的参与者中。一系列亚组分析和敏感性分析显示了相似的结果。总体而言，我们的研究结果强调了保持最佳膳食铜摄入量水平对于预防过早死亡的重要性。
