Department of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan 7 Road, Beijing 100191, China.
Beifang Branch of Peking University Third Hospital, Chedaogou No. 10, Beijing 100089, China.
Nutrients. 2024 Feb 5;16(3):455. doi: 10.3390/nu16030455.
This study aims to examine the relationship between dietary inflammatory index (DII) and bone mineral density (BMD) changes among Chinese pregnant women, offering valuable insights for dietary guidance during pregnancy.
289 pregnant women were enrolled in this cohort. Serum inflammatory factors and ultrasonic BMD were measured at the first, second, and the third trimesters. DII scores were calculated based on a semi-quantitative food frequency questionnaire (FFQ) and divided into tertiles. We compared the differences in inflammatory factors in serum across the tertiles of DII and changes in BMD at the second and third trimesters across the tertiles.
The participants with higher DII scores had higher total energy intakes than those with lower DII scores. The serum level of interleukin-6 (IL-6) was significantly different across the tertiles of the DII. Women who had lower DII scores had higher T-scores and Z-scores in the BMD assessment. In the test of trends, after adjusting potential covariates, including educational level, physical activity, body mass index, and calcium, vitamin D, or multivitamin supplements, DII values were determined to be positively related to the maternal BMD lost.
DII was positively associated with serum IL-6. Meanwhile, higher DII scores were associated with more bone mass loss in pregnant women. We recommend adhering to a lower-DII diet to preserve BMD during pregnancy.
本研究旨在探讨中国孕妇饮食炎症指数（DII）与骨密度（BMD）变化之间的关系，为孕期饮食指导提供有价值的参考。
本队列纳入了 289 名孕妇。在孕早期、孕中期和孕晚期分别测量血清炎症因子和超声 BMD。根据半定量食物频率问卷（FFQ）计算 DII 评分，并将其分为三分位。我们比较了不同 DII 三分位组血清中炎症因子的差异，以及不同 DII 三分位组孕中期和孕晚期 BMD 的变化。
DII 评分较高的孕妇总能量摄入高于 DII 评分较低的孕妇。血清白细胞介素-6（IL-6）水平在 DII 的三分位组间存在显著差异。DII 评分较低的孕妇在 BMD 评估中 T 评分和 Z 评分较高。在趋势检验中，调整了潜在的混杂因素，包括教育水平、体力活动、体重指数以及钙、维生素 D 或多种维生素补充剂后，DII 值与产妇 BMD 丢失呈正相关。
DII 与血清 IL-6 呈正相关。同时，较高的 DII 评分与孕妇更多的骨量丢失有关。我们建议在孕期遵循低 DII 饮食以维持 BMD。
