The First Affiliated Hospital of Harbin Medical University, People's Republic of China.
The First Affiliated Hospital of Harbin Medical University, People's Republic of China.
Peptides. 2023 Jun;164:170991. doi: 10.1016/j.peptides.2023.170991. Epub 2023 Mar 11.
Spexin, also identified as neuropeptide Q (NPQ), is a 14 amino acid peptide discovered by bioinformatic methods. It has a conserved structure in many species and is widely expressed in the central nervous system and peripheral tissues. It has an associated receptor, galanin receptor 2/3 (GALR2/3). Mature spexin peptides can exert various functions by activating GALR2/3, such as inhibiting food intake, inhibiting lipid absorption, reducing body weight, and improving insulin resistance. Spexin is expressed in the adrenal gland, pancreas, visceral fat, and thyroid, with the highest expression in the adrenal gland, followed by the pancreas. Physiologically, spexin and insulin interact in pancreatic islets. Spexin may be one of the regulators of endocrine function in the pancreas. Spexin is a possible indicator of insulin resistance and it has a variety of functional properties, here we review its role in energy metabolism.
Spexin，也被鉴定为神经肽 Q（NPQ），是一种由生物信息学方法发现的 14 个氨基酸肽。它在许多物种中具有保守的结构，广泛表达于中枢神经系统和外周组织中。它具有相关的受体，甘丙肽受体 2/3（GALR2/3）。成熟的 spexin 肽可以通过激活 GALR2/3 发挥各种功能，例如抑制食欲、抑制脂质吸收、减轻体重和改善胰岛素抵抗。Spexin 在肾上腺、胰腺、内脏脂肪和甲状腺中表达，在肾上腺中的表达最高，其次是胰腺。在生理上，spexin 和胰岛素在胰岛中相互作用。Spexin 可能是胰腺内分泌功能的调节剂之一。Spexin 是胰岛素抵抗的一个可能指标，它具有多种功能特性，在这里我们综述其在能量代谢中的作用。
