Medical Immunology, Aziz Sancar Institute of Experimental Medicine, İstanbul University, Istanbul, Turkey.
Student Research Committee, Department of Food Science and Technology, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Biochem Biophys Res Commun. 2024 Apr 2;702:149632. doi: 10.1016/j.bbrc.2024.149632. Epub 2024 Feb 5.
The interplay between gut microbiota and human health, both mental and physical, is well-documented. This connection extends to the gut-brain-skin axis, linking gut microbiota to skin health. Recent studies have underscored the potential of probiotics and prebiotics to modulate gut microbiota, supported by in vivo and clinical investigations. In this comprehensive review, we explore the immunological implications of probiotics in influencing the gut-skin axis for the treatment and prevention of skin conditions, including psoriasis, acne, diabetic ulcers, atopic dermatitis, and skin cancer. Our analysis reveals that probiotics exert their effects by modulating cytokine production, whether administered orally or topically. Probiotics bolster skin defenses through the production of antimicrobial peptides and the induction of keratinocyte differentiation and regeneration. Yet, many questions surrounding probiotics remain unanswered, necessitating further exploration of their mechanisms of action in the context of skin diseases.
肠道微生物群与人类身心健康的相互作用已有充分的文献记载。这种联系延伸到了肠道-大脑-皮肤轴，将肠道微生物群与皮肤健康联系起来。最近的研究强调了益生菌和益生元调节肠道微生物群的潜力，这得到了体内和临床研究的支持。在这篇全面的综述中，我们探讨了益生菌对影响肠道-皮肤轴的免疫影响，以治疗和预防皮肤疾病，包括银屑病、痤疮、糖尿病溃疡、特应性皮炎和皮肤癌。我们的分析表明，益生菌通过调节细胞因子的产生发挥作用，无论是口服还是局部给药。益生菌通过产生抗菌肽和诱导角质形成细胞分化和再生来增强皮肤防御能力。然而，益生菌仍有许多问题尚未得到解答，需要进一步探索其在皮肤疾病中的作用机制。
