Department of Food Science and Technology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, 19496-35881, Iran.
Iranian Research Organization for Science and Technology, Microbial Biotechnology Student in Iranian Research Organization for Science and Technology, Microbial biotechnology, Tehran, 3353511, Iran.
Probiotics Antimicrob Proteins. 2024 Dec;16(6):2132-2149. doi: 10.1007/s12602-024-10319-y. Epub 2024 Jul 5.
The skin, being the largest organ in the human body, plays a pivotal role in safeguarding the body against invasive pathogens. Therefore, it is essential to reinforce and protect this vital organ. Current research supports the impact of probiotics on skin health and their ability to alleviate various skin disorders. However, the effectiveness and probable side effects of probiotics in skin care remain a subject of debate, necessitating further investigation and analysis. Hence, this study aims to highlight existing gaps and future needs in the current research on probiotics in skin care and pave the way for future investigations. Therefore, we scrutinized the effects of oral (fermented foods and dietary supplements) and non-oral/topical probiotics on skin care, and the mechanism of probiotics that affect skin health. The results of most studies showed that fermented foods containing probiotics, particularly dairy products, positively impact skin health. The research results regarding the efficacy of probiotic supplements and live strains in treating skin disorders show promising potential. However, safety evaluations are crucial, to identify any potential adverse effects. While research has identified numerous potential mechanisms by which probiotics may influence skin health, a complete understanding of their precise mode of action remains elusive. However, it seems that probiotics can exert their positive effects through the gut-skin and gut-skin-brain axis on the human body. Therefore, following the identification of safe probiotics, additional studies should be carried out to establish optimal dosages, potential side effects, suitable regulatory guidelines, and validation methods.
皮肤作为人体最大的器官，在保护身体免受入侵病原体的侵害方面起着关键作用。因此，加强和保护这个重要的器官是至关重要的。目前的研究支持益生菌对皮肤健康的影响及其缓解各种皮肤疾病的能力。然而，益生菌在皮肤护理中的有效性和可能的副作用仍然存在争议，需要进一步的研究和分析。因此，本研究旨在强调益生菌在皮肤护理研究中的现有差距和未来需求，并为未来的研究铺平道路。因此，我们研究了口服（发酵食品和膳食补充剂）和非口服/局部益生菌对皮肤护理的影响，以及影响皮肤健康的益生菌机制。大多数研究的结果表明，含有益生菌的发酵食品，特别是乳制品，对皮肤健康有积极的影响。关于益生菌补充剂和活菌在治疗皮肤疾病方面的功效的研究结果显示出有希望的潜力。然而，安全性评估至关重要，以确定任何潜在的不良反应。虽然研究已经确定了益生菌可能影响皮肤健康的许多潜在机制，但对其确切作用机制仍未完全了解。然而，似乎益生菌可以通过肠道-皮肤和肠道-皮肤-大脑轴对人体发挥其积极作用。因此，在确定安全的益生菌后，应进行更多的研究，以确定最佳剂量、潜在副作用、合适的监管指南和验证方法。
