文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

一种从苏木精-伊红染色的全切片图像中检测正常和结核感染肺部的计算框架。

A Computational Framework to Detect Normal and Tuberculosis Infected Lung from H&E-stained Whole Slide Images.

作者信息

Niazi M Khalid Khan, Beamer Gillian, Gurcan Metin N

机构信息

Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio, USA.

Department of Infectious Disease and Global Health, Tufts University, Grafton, Massachusetts, USA.

出版信息

Proc SPIE Int Soc Opt Eng. 2017 Feb;10140. doi: 10.1117/12.2255627. Epub 2017 Mar 1.


DOI:10.1117/12.2255627
PMID:38347946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10860644/
Abstract

Accurate detection and quantification of normal lung tissue in the context of infection is of interest from a biological perspective. The automatic detection and quantification of normal lung will allow the biologists to focus more intensely on regions of interest within normal and infected tissues. We present a computational framework to extract individual tissue sections from whole slide images having multiple tissue sections. It automatically detects the background, red blood cells and handwritten digits to bring efficiency as well as accuracy in quantification of tissue sections. For efficiency, we model our framework with logical and morphological operations as they can be performed in linear time. We further divide these individual tissue sections into normal and infected areas using deep neural network. The computational framework was trained on 60 whole slide images. The proposed computational framework resulted in an overall accuracy of 99.2% when extracting individual tissue sections from 120 whole slide images in the test dataset. The framework resulted in a relatively higher accuracy (99.7%) while classifying individual lung sections into normal and infected areas. Our preliminary findings suggest that the proposed framework has good agreement with biologists on how define normal and infected lung areas.

摘要

从生物学角度来看,在感染背景下准确检测和定量正常肺组织具有重要意义。正常肺组织的自动检测和定量将使生物学家能够更专注于正常组织和感染组织中的感兴趣区域。我们提出了一个计算框架,用于从具有多个组织切片的全切片图像中提取单个组织切片。它能自动检测背景、红细胞和手写数字,从而在组织切片定量方面提高效率和准确性。为了提高效率,我们用逻辑和形态学操作对框架进行建模,因为这些操作可以在线性时间内执行。我们进一步使用深度神经网络将这些单个组织切片划分为正常区域和感染区域。该计算框架在60张全切片图像上进行了训练。当从测试数据集中的120张全切片图像中提取单个组织切片时,所提出的计算框架总体准确率达到了99.2%。在将单个肺切片分类为正常区域和感染区域时,该框架的准确率相对较高(99.7%)。我们的初步研究结果表明,所提出的框架在如何定义正常和感染肺区域方面与生物学家的观点具有良好的一致性。

相似文献

[1]
A Computational Framework to Detect Normal and Tuberculosis Infected Lung from H&E-stained Whole Slide Images.

Proc SPIE Int Soc Opt Eng. 2017-2

[2]
Multimodal Lung Cancer Subtyping Using Deep Learning Neural Networks on Whole Slide Tissue Images and MALDI MSI.

Cancers (Basel). 2022-12-14

[3]
Use of Deep Learning to Develop and Analyze Computational Hematoxylin and Eosin Staining of Prostate Core Biopsy Images for Tumor Diagnosis.

JAMA Netw Open. 2020-5-1

[4]
An application of transfer learning to neutrophil cluster detection for tuberculosis: Efficient implementation with nonmetric multidimensional scaling and sampling.

Proc SPIE Int Soc Opt Eng. 2018

[5]
A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging.

EJNMMI Res. 2013-7-23

[6]
Attention2majority: Weak multiple instance learning for regenerative kidney grading on whole slide images.

Med Image Anal. 2022-7

[7]
A CNN-based active learning framework to identify mycobacteria in digitized Ziehl-Neelsen stained human tissues.

Comput Med Imaging Graph. 2020-9

[8]
Deep Learning to Estimate Human Epidermal Growth Factor Receptor 2 Status from Hematoxylin and Eosin-Stained Breast Tissue Images.

J Pathol Inform. 2020-7-24

[9]
Recognizing basal cell carcinoma on smartphone-captured digital histopathology images with a deep neural network.

Br J Dermatol. 2020-3

[10]
On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at .

J Am Soc Mass Spectrom. 2021-11-3

引用本文的文献

[1]
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic lung infection in Diversity Outbred mice.

Infect Immun. 2024-7-11

[2]
Systems genetics uncover new loci containing functional gene candidates in Mycobacterium tuberculosis-infected Diversity Outbred mice.

PLoS Pathog. 2024-6

[3]
Systems genetics uncover new loci containing functional gene candidates in -infected Diversity Outbred mice.

bioRxiv. 2023-12-22

[4]
An application of transfer learning to neutrophil cluster detection for tuberculosis: Efficient implementation with nonmetric multidimensional scaling and sampling.

Proc SPIE Int Soc Opt Eng. 2018

[5]
Deep learning predicts gene expression as an intermediate data modality to identify susceptibility patterns in Mycobacterium tuberculosis infected Diversity Outbred mice.

EBioMedicine. 2021-5

[6]
Automatic discovery of clinically interpretable imaging biomarkers for Mycobacterium tuberculosis supersusceptibility using deep learning.

EBioMedicine. 2020-12

[7]
Automatic Detection of Granuloma Necrosis in Pulmonary Tuberculosis Using a Two-Phase Algorithm: 2D-TB.

Microorganisms. 2019-12-7

[8]
DeepFocus: Detection of out-of-focus regions in whole slide digital images using deep learning.

PLoS One. 2018-10-25

[9]
Identifying tumor in pancreatic neuroendocrine neoplasms from Ki67 images using transfer learning.

PLoS One. 2018-4-12

本文引用的文献

[1]
Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice.

Dis Model Mech. 2015-9

[2]
Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis.

Immun Ageing. 2014-12-16

[3]
Deep learning in neural networks: an overview.

Neural Netw. 2015-1

[4]
Perceptual clustering for automatic hotspot detection from Ki-67-stained neuroendocrine tumour images.

J Microsc. 2014-12

[5]
Detecting and characterizing cellular responses to Mycobacterium tuberculosis from histology slides.

Cytometry A. 2014-2

[6]
Hue-saturation-density (HSD) model for stain recognition in digital images from transmitted light microscopy.

Cytometry. 2000-4-1

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索