口服多西环素在潜伏梅毒或神经梅毒患者脑脊液中的穿透情况。
Penetration of oral doxycycline into the cerebrospinal fluid of patients with latent or neurosyphilis.
作者信息
Yim C W, Flynn N M, Fitzgerald F T
出版信息
Antimicrob Agents Chemother. 1985 Aug;28(2):347-8. doi: 10.1128/AAC.28.2.347.
Abstract
Five patients with laboratory evidence of latent or neurosyphilis were treated orally with doxycycline (200 mg) twice a day for 21 days. After the seventh dose, the mean level of doxycycline in serum was 5.8 micrograms/ml, with a mean drug level in cerebrospinal fluid of 1.3 micrograms/ml. The mean penetration into cerebrospinal fluid was 26%. These preliminary findings suggest that doxycycline, administered orally at a dose of 200 mg twice a day, reaches a sufficient concentration in cerebrospinal fluid to be worthy of further evaluation as an alternative regimen to penicillin therapy for latent or neurosyphilis.
摘要
五名有潜伏性梅毒或神经梅毒实验室证据的患者口服强力霉素（200毫克），每日两次，共21天。第七剂后，血清中强力霉素的平均水平为5.8微克/毫升，脑脊液中的平均药物水平为1.3微克/毫升。进入脑脊液的平均渗透率为26%。这些初步研究结果表明，每日两次口服200毫克剂量的强力霉素在脑脊液中可达到足够的浓度，作为潜伏性或神经梅毒青霉素治疗的替代方案值得进一步评估。
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