Bradley-Moore A M, Greenwood B M, Bradley A K, Bartlett A, Bidwell D E, Voller A, Craske J, Kirkwood B R, Gilles H M
Ann Trop Med Parasitol. 1985 Dec;79(6):563-73. doi: 10.1080/00034983.1985.11811963.
The immune response of 198 young Nigerian children protected against malaria by chemoprophylaxis with chloroquine to immunization with triple, poliomyelitis, measles, typhoid, meningococcal and BCG vaccines was compared with the immune response to vaccination of 185 control children. Good responses to triple, measles and BCG vaccines were shown by children in both groups; poorer responses were obtained to poliomyelitis, typhoid and meningococcal vaccines. The response to immunization of protected children was similar to that observed among control children for all the vaccines tested except for meningococcal polysaccharide vaccine. Protected children showed a significantly greater antibody response to both group A and group C meningococcal polysaccharides than control children. This finding supports the results of previous studies which have shown that the immune response to meningococcal polysaccharide vaccines is adversely affected both by acute malaria and by asymptomatic malaria parasitaemia.
将198名通过氯喹化学预防法预防疟疾的尼日利亚儿童对三联疫苗、脊髓灰质炎疫苗、麻疹疫苗、伤寒疫苗、脑膜炎球菌疫苗和卡介苗的免疫反应，与185名对照儿童的疫苗接种免疫反应进行了比较。两组儿童对三联疫苗、麻疹疫苗和卡介苗均表现出良好反应；而对脊髓灰质炎疫苗、伤寒疫苗和脑膜炎球菌疫苗的反应较差。除脑膜炎球菌多糖疫苗外，在所有测试疫苗中，受保护儿童的免疫反应与对照儿童中观察到的相似。受保护儿童对A组和C组脑膜炎球菌多糖的抗体反应明显高于对照儿童。这一发现支持了先前研究的结果，即急性疟疾和无症状疟疾寄生虫血症均会对脑膜炎球菌多糖疫苗的免疫反应产生不利影响。
