Udezue E O
Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu.
Trans R Soc Trop Med Hyg. 1989 Jan-Feb;83(1):63-5. doi: 10.1016/0035-9203(89)90706-2.
Prophylaxis of malaria and frequency of clinical attacks were studied in a group of Nigerian children who were born abroad and recently returned home. Two control groups of young children, born and resident in Nigeria, were studied in the same way: one group was protected against malaria and the other was not. Malarial immunofluorescent antibody (IFA) was measured in all 3 groups. All the groups had high IFA positivity rates of 79% or over, but titres were low in the children born abroad, higher in the Nigerian-born protected children, and highest in the unprotected group. Frequency of clinical malaria was the same in both groups of protected children whether born abroad or locally. There appeared to be no long-term advantage in giving regular malaria chemoprophylaxis to children of semi-immune mothers returning permanently to malarious countries, if the parents were alert to provide prompt treatment of clinical malaria.
对一群在国外出生且近期回国的尼日利亚儿童的疟疾预防及临床发作频率进行了研究。以同样方式对两组在尼日利亚出生并居住的幼儿进行了研究：一组采取了疟疾预防措施，另一组未采取。对所有三组儿童均检测了疟疾免疫荧光抗体（IFA）。所有三组的IFA阳性率均较高，达到79%或更高，但在国外出生的儿童中抗体滴度较低，在尼日利亚出生且采取预防措施的儿童中滴度较高，而在未采取预防措施的组中滴度最高。无论在国外出生还是在当地出生，两组采取预防措施的儿童临床疟疾发作频率相同。对于半免疫母亲的子女永久性返回疟疾流行国家的情况，如果父母能警觉地对临床疟疾进行及时治疗，定期给予疟疾化学预防似乎没有长期益处。
