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动脉瘤样纤维组织细胞瘤：一种采用姑息性放射治疗和靶向治疗的伴有转移的大型软组织肿瘤。

Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy.

作者信息

Chamberlin Michael, Khan Sophia, Hernandez Cristal, Miettinen Markku, Wei Jun S, Khan Javed, Glod John, Rowe Lindsay, Kaushal Aradhana

机构信息

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

出版信息

Case Rep Oncol. 2021 Feb 9;14(1):17-23. doi: 10.1159/000511073. eCollection 2021 Jan-Apr.

DOI:10.1159/000511073
PMID:38352276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10862073/
Abstract

Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.

摘要

动脉瘤样纤维组织细胞瘤（AFH）是皮肤纤维组织细胞瘤的一种罕见变体，恶性潜能低，转移进展不常见。我们报告了一例19岁女性患者，其颈部有一个巨大的AFH转移至软组织，接受了放射治疗和分子靶向治疗。据我们所知，这是第一份描述在这种罕见恶性肿瘤中使用放射治疗和姑息治疗或靶向治疗的报告，可为未来的治疗策略提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/8d4f4a56b509/cro-0014-0017-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/60e2999a7e9b/cro-0014-0017-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/21b9230372d5/cro-0014-0017-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/8d4f4a56b509/cro-0014-0017-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/60e2999a7e9b/cro-0014-0017-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/21b9230372d5/cro-0014-0017-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78f0/10862073/8d4f4a56b509/cro-0014-0017-g03.jpg

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Diseases. 2023 Aug 23;11(3):108. doi: 10.3390/diseases11030108.

本文引用的文献

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Indian Dermatol Online J. 2015 Nov-Dec;6(6):436-8. doi: 10.4103/2229-5178.169740.
2
LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13).通过RNA测序在伴有t(3;11)(p21;q13)的动脉瘤性良性纤维组织细胞瘤中鉴定出的LAMTOR1-PRKCD和NUMA1-SFMBT1融合基因。
Cancer Genet. 2015 Nov;208(11):545-51. doi: 10.1016/j.cancergen.2015.07.007. Epub 2015 Aug 3.
3
Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing.
使用荧光原位杂交和RNA测序检测福尔马林固定石蜡包埋的良性纤维组织细胞瘤中的基因融合
Lab Invest. 2015 Sep;95(9):1071-6. doi: 10.1038/labinvest.2015.83. Epub 2015 Jun 29.
4
CyberKnife radiotherapy for malignant fibrous histiocytoma of the chest wall: A case report and review of the literature.射波刀治疗胸壁恶性纤维组织细胞瘤：1例报告并文献复习
Oncol Lett. 2014 Jun;7(6):1877-1880. doi: 10.3892/ol.2014.1995. Epub 2014 Mar 24.
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