Ohshio G, Furukawa F, Fujiwara H, Hamashima Y
Pediatr Pathol. 1985;4(3-4):257-64. doi: 10.3109/15513818509026899.
Pathologic studies of the liver were performed on 30 autopsied cases of Kawasaki disease. The cases were classified into four groups (stages I-IV), and stage IV was further divided into two subgroups according to the duration of the illness at the time of death. Liver weights were markedly increased in stage II (12-25 days) and in stage III (28-36 days) but returned to normal in stage IVb (7 months to 6 years). Likewise, spleen weights were also markedly increased in stages II and III. Stage I (0-9 days) and stage II were characterized by acute inflammation in portal area, and degree of inflammatory changes decreased gradually. There was significant correlation between hepatomegaly and the degree of inflammation in portal areas, but not with definite heart failure or the use of drugs. These data suggest that the pathogenesis of hepatomegaly in acute-stage Kawasaki disease involves the inflammation in portal areas and/or latent heart failure.
对30例川崎病尸检病例进行了肝脏病理研究。这些病例被分为四组（I-IV期），IV期又根据死亡时疾病持续时间进一步分为两个亚组。肝脏重量在II期（12-25天）和III期（28-36天）显著增加，但在IVb期（7个月至6年）恢复正常。同样，脾脏重量在II期和III期也显著增加。I期（0-9天）和II期的特征是门脉区急性炎症，炎症变化程度逐渐降低。肝肿大与门脉区炎症程度之间存在显著相关性，但与明确的心力衰竭或药物使用无关。这些数据表明，急性期川崎病肝肿大的发病机制涉及门脉区炎症和/或潜在心力衰竭。
