Simon B, Kather H
Digestion. 1979;19(2):137-9. doi: 10.1159/000198335.
Prostacyclin, its stable metabolite 6-keto-prostaglandin F1 alpha and prostaglandin E2 were tested on the adenylate cyclase system in human gastric mucosa. All three compounds were able to activate human cyclase. Saturating concentrations of prostacyclin, prostaglandin E2 and 6-keto-prostaglandin F1 alpha (each 0.28 mM) increased the enzyme activity 3.0 and 1.6 fold, respectively. The concentrations of prostacyclin and prostaglandin E2 required to produce half maximal activation were in the same range. Prostacyclin is an efficient stimulator of human gastric mucosal adenylate cyclase.
前列环素、其稳定代谢产物6-酮-前列腺素F1α和前列腺素E2在人胃黏膜的腺苷酸环化酶系统上进行了测试。这三种化合物均能激活人环化酶。前列环素、前列腺素E2和6-酮-前列腺素F1α的饱和浓度（均为0.28 mM）分别使酶活性提高了3.0倍和1.6倍。产生半数最大激活所需的前列环素和前列腺素E2浓度在同一范围内。前列环素是一种高效的人胃黏膜腺苷酸环化酶刺激剂。
