胃体、胃窦和十二指肠黏膜活检标本中对前列环素2敏感的人腺苷酸环化酶。

PGI2-sensitive human adenylate cyclase in biopsy specimens of corpus, antral and duodenal mucosa.

作者信息

Simon B, Kather H

出版信息

Digestion. 1980;20(2):111-4. doi: 10.1159/000198427.

DOI:10.1159/000198427

Abstract

The distribution of prostacyclin-(PGI2-)sensitive cyclase in human gastric and duodenal mucosa was studied. Like PGE2, PGI2 induced a dose-dependent increase of enzyme activity throughout the stomach and the duodenum. Maximal effects (about 2.5- to 3.0-fold increase) were observed at a PGI2 concentration of 0.28 mmol/l. The stable breakdown product 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) was much less active. The equal distribution of the PGI2-sensitive adenylate cyclase in the human upper alimentary tract suggests a localization of this enzyme system in cells not directly related to gastric acid secretion.

摘要

研究了前列环素（PGI2）敏感环化酶在人胃和十二指肠黏膜中的分布。与前列腺素E2（PGE2）一样，PGI2在整个胃和十二指肠中诱导酶活性呈剂量依赖性增加。在PGI2浓度为0.28 mmol/l时观察到最大效应（增加约2.5至3.0倍）。稳定的分解产物6-酮-前列腺素F1α（6-酮-PGF1α）的活性要低得多。PGI2敏感的腺苷酸环化酶在人上消化道中的均匀分布表明该酶系统定位于与胃酸分泌无直接关系的细胞中。