用于预防、治疗和延缓乳腺癌进展的天然产物
Natural Products for the Prevention, Treatment and Progression of Breast Cancer.
作者信息
Svolacchia Fabiano, Brongo Sergio, Catalano Alessia, Ceccarini Agostino, Svolacchia Lorenzo, Santarsiere Alessandro, Scieuzo Carmen, Salvia Rosanna, Finelli Francesca, Milella Luigi, Saturnino Carmela, Sinicropi Maria Stefania, Fabrizio Tommaso, Giuzio Federica
机构信息
Department of Medical-Surgical Sciences and Biotechnologies, La Sapienza University, 00118 Rome, Italy.
Department of Medical Sciences, Policlinic Foundation Tor Vergata University, 00133 Rome, Italy.
出版信息
Cancers (Basel). 2023 May 30;15(11):2981. doi: 10.3390/cancers15112981.
In this review, we summarize the most used natural products as useful adjuvants in BC by clarifying how these products may play a critical role in the prevention, treatment and progression of this disease. BC is the leading cancer, in terms of incidence, that affects women. The epidemiology and pathophysiology of BC were widely reported. Inflammation and cancer are known to influence each other in several tumors. In the case of BC, the inflammatory component precedes the development of the neoplasm through a slowly increasing and prolonged inflammation that also favors its growth. BC therapy involves a multidisciplinary approach comprising surgery, radiotherapy and chemotherapy. There are numerous observations that showed that the effects of some natural substances, which, in integration with the classic protocols, can be used not only for prevention or integration in order to prevent recurrences and induce a state of chemoquiescence but also as chemo- and radiosensitizers during classic therapy.
在本综述中，我们通过阐明这些天然产物如何在乳腺癌的预防、治疗和病程中发挥关键作用，总结了在乳腺癌中最常用的作为有益佐剂的天然产物。乳腺癌是女性中发病率最高的癌症。乳腺癌的流行病学和病理生理学已有广泛报道。已知炎症和癌症在几种肿瘤中相互影响。就乳腺癌而言，炎症成分通过缓慢增加和持续的炎症在肿瘤形成之前就已存在，这种炎症也有利于肿瘤生长。乳腺癌治疗涉及多学科方法，包括手术、放疗和化疗。有大量观察结果表明，一些天然物质与经典方案相结合，不仅可用于预防或补充以防止复发并诱导化学静止状态，还可在经典治疗期间作为化学增敏剂和放射增敏剂。
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