Njokanma Azuka Raphael, Fatusi Olawunmi Adedoyin, Ogundipe Olufemi Kolawole, Arije Olujide Olusesan, Akomolafe Ayodele Gbenga, Kuye Olasunkanmi Funmilola
Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Korean Assoc Oral Maxillofac Surg. 2022 Dec 31;48(6):371-381. doi: 10.5125/jkaoms.2022.48.6.371.
This study determined the effect of platelet-rich fibrin (PRF) on extraction socket bone regeneration and assessed the patterns and determinants of bone regeneration after the surgical extraction of impacted mandibular third molars.
This prospective study randomly allocated 90 patients into two treatment groups: A PRF group (intervention group) and a non-PRF group (control group). After surgical extractions, the PRF group had PRF placed in the extraction socket and the socket was sutured, while the socket was only sutured in the non-PRF group. At postoperative weeks 1, 4, 8, and 12, periapical radiographs were obtained and HLImage software was used to determine the region of newly formed bone (RNFB) and the pattern of bone formation. The determinants of bone regeneration were assessed. Statistical significance was set at <0.05.
The percentage RNFB (RNFB%) was not significantly higher in the PRF group when compared with the non-PRF group at postoperative weeks 1, 4, 8, and 12 (=0.188, 0.155, 0.132, and 0.219, respectively). Within the non-PRF group, the middle third consistently exhibited the highest bone formation while the least amount of bone formation was consistently observed in the cervical third. In the PRF group, the middle third had the highest bone formation, while bone formation at the apical third was smaller compared to the cervical third at the 8th week with this difference widening at the 12th week. The sex of the patient, type of impaction, and duration of surgery was significantly associated with percentage bone formation (=0.041, 0.043, and 0.018, respectively).
Placement of PRF in extraction sockets increased socket bone regeneration. However, this finding was not statistically significant. The patient's sex, type of impaction, and duration of surgery significantly influenced the percentage of bone formation.
本研究确定富血小板纤维蛋白（PRF）对拔牙窝骨再生的影响，并评估下颌阻生第三磨牙手术拔除后骨再生的模式和决定因素。
本前瞻性研究将90例患者随机分为两个治疗组：PRF组（干预组）和非PRF组（对照组）。手术拔牙后，PRF组将PRF置于拔牙窝并缝合创口，而非PRF组仅缝合创口。在术后第1、4、8和12周，拍摄根尖片，并用HLImage软件确定新形成骨区域（RNFB）和骨形成模式。评估骨再生的决定因素。设定统计学显著性水平为<0.05。
在术后第1、4、8和12周，PRF组的RNFB百分比（RNFB%）与非PRF组相比无显著更高（分别为=0.188、0.155、0.132和=0.219）。在非PRF组中，中三分之一区域始终表现出最高的骨形成，而在颈部三分之一区域始终观察到最少的骨形成。在PRF组中，中三分之一区域骨形成最高，而在第8周时根尖三分之一区域的骨形成比颈部三分之一区域小，这种差异在第12周时扩大。患者的性别、阻生类型和手术持续时间与骨形成百分比显著相关（分别为=0.041、0.043和=0.018）。
在拔牙窝中放置PRF可增加牙槽骨再生。然而，这一发现无统计学显著性。患者的性别、阻生类型和手术持续时间显著影响骨形成百分比。
