Department of Pediatrics, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Front Immunol. 2024 Jan 31;15:1335042. doi: 10.3389/fimmu.2024.1335042. eCollection 2024.
Pregnancy outcomes of patients with systemic lupus erythematosus (SLE) have improved over the past four decades, leading to an increased desire for pregnancy among this cohort. However, the offspring of patients with SLE still face the risks of preterm birth, low birth weight, learning disabilities, and neurological disorders, while the causes underlying these risks remain unclear.
In this study, we analyzed the blood metabolic features of neonates born to 30 SLE patients and 52 healthy control mothers by employing tandem mass spectrometry with the dual aims of identifying the etiology of metabolic features specific to infants born from mothers with SLE and providing new insights into the clinical management of such infants.
We found significant differences in serum metabolite levels between infants born from mothers with SLE and those born from mothers without SLE, including 15 metabolites with reduced serum levels. Further analysis revealed a disrupted tyrosine metabolism pathway in the offspring of mothers with SLE.
By constructing a composite model incorporating various factors, such as serum tyrosine levels, gestational age, and birth weight, we were able to accurately differentiate between newborns of SLE and non-SLE pregnancies. Our data reveal significant differences in serum concentrations of amino acids and acylcarnitines in newborns born to mothers with SLE. We conclude that the reduction of blood L-tyrosine levels is a feature that is characteristic of adverse neurological outcomes in infants born from mothers with SLE.
过去四十年中，系统性红斑狼疮（SLE）患者的妊娠结局得到了改善，这导致该人群对妊娠的渴望增加。然而，SLE 患者的后代仍然面临早产、低出生体重、学习障碍和神经发育障碍的风险，而这些风险的根本原因仍不清楚。
本研究通过串联质谱法分析了 30 例 SLE 患者和 52 例健康对照母亲所生新生儿的血液代谢特征，旨在确定 SLE 母亲所生婴儿特有的代谢特征的病因，并为这些婴儿的临床管理提供新的见解。
我们发现 SLE 母亲所生婴儿和非 SLE 母亲所生婴儿的血清代谢物水平存在显著差异，包括 15 种血清水平降低的代谢物。进一步分析显示，SLE 母亲的后代存在酪氨酸代谢途径紊乱。
通过构建一个包含血清酪氨酸水平、胎龄和出生体重等多种因素的综合模型，我们能够准确地区分 SLE 和非 SLE 妊娠的新生儿。我们的数据显示，SLE 母亲所生新生儿的血清氨基酸和酰基肉碱浓度存在显著差异。我们得出结论，血液 L-酪氨酸水平降低是 SLE 母亲所生婴儿不良神经发育结局的特征。
