Iino Y, Yuasa R, Kaneko Y, Takasaka T, Kawamoto K
Auris Nasus Larynx. 1985;12 Suppl 1:S94-6. doi: 10.1016/s0385-8146(85)80113-9.
Endotoxin in persistent middle ear effusions (MEEs) from children with acute otitis media (AOM) whose acute inflammation had cleared was assayed by Limulus test, parallel with the detection of bacteria. Seventy-five percents of MEEs were endotoxin positive, and the concentration of endotoxin in MEE was not related to the interval between the onset of AOM and the date of sample collection. However, the cases with MEE that had high concentration of endotoxin tended to have persistent MEE for more than one month after sample collection. Therefore, the presence of endotoxin may be one of the causal factors of a delayed recovery of AOM and of the development of otitis media with effusion.
对急性中耳炎（AOM）患儿急性炎症已消退后的持续性中耳积液（MEE）进行内毒素检测，并与细菌检测同步进行。结果显示，75%的MEE内毒素呈阳性，且MEE内毒素浓度与AOM发病至样本采集日期之间的间隔无关。然而，MEE内毒素浓度高的病例在样本采集后往往会持续存在MEE超过一个月。因此，内毒素的存在可能是AOM延迟恢复和中耳积液性中耳炎发生的原因之一。
