Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.
Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia.
Sci Total Environ. 2024 Apr 10;920:170781. doi: 10.1016/j.scitotenv.2024.170781. Epub 2024 Feb 13.
Synthetic opioids, particularly the nitazene analogues class, have become a public health concern due to their high potency. Wastewater-based epidemiology can detect community use of these compounds. The objective of this work was to detect nitazene analogues in wastewater from samples collected from eight sites in the United States. Influent wastewater samples were collected from eight sites in seven states (Arizona, Oregon, New Mexico, Illinois, New Jersey, Washington and Georgia) in the United States. Samples were collected from each site on three days between 27 December 2022 and 4 January 2023, acidified on collection, stored frozen and shipped to Arizona State University (Tempe, AZ) for sample processing. Samples were then shipped to The University of Queensland (Brisbane, Australia) for sample analysis. Protonitazene was found in samples collected from two sites in Washington and Illinois. The concentration was estimated up to 0.5 ng/L, with estimated excreted mass loads up to 0.3 mg/day/1000 people. This work has shown that it is possible to detect nitazene analogues in wastewater using a combination of sample pre-concentration and sensitive instrumentation, thereby further expanding the utility of wastewater-based epidemiology.
合成阿片类药物，特别是硝甲西泮类似物类，由于其高效力而成为公共卫生关注的焦点。基于污水的流行病学可以检测到这些化合物在社区中的使用情况。本工作的目的是检测从美国八个地点采集的污水中的硝甲西泮类似物。从美国七个州（亚利桑那州、俄勒冈州、新墨西哥州、伊利诺伊州、新泽西州、华盛顿州和佐治亚州）的八个地点采集了污水样本。于 2022 年 12 月 27 日至 2023 年 1 月 4 日期间的三天内，每天从每个地点采集样本，采集时酸化，冷冻储存并运往亚利桑那州立大学（坦佩，AZ）进行样品处理。然后将样品运往昆士兰大学（布里斯班，澳大利亚）进行样品分析。在华盛顿州和伊利诺伊州的两个地点采集的样本中发现了普萘洛尔。浓度估计高达 0.5ng/L，估计排泄的质量负荷高达 0.3mg/天/1000 人。这项工作表明，使用样品预浓缩和灵敏仪器的组合可以在污水中检测到硝甲西泮类似物，从而进一步扩展了基于污水的流行病学的应用。
