在未对数据进行全面筛选的情况下篡改火山图。
Fudging the volcano-plot without dredging the data.
作者信息
Burger Thomas
机构信息
Univ. Grenoble Alpes, INSERM, CEA, UA13 BGE, CNRS, CEA, FR2048 ProFI, 38000, Grenoble, France.
出版信息
Nat Commun. 2024 Feb 15;15(1):1392. doi: 10.1038/s41467-024-45834-7.
Abstract
Selecting omic biomarkers using both their effect size and their differential status significance (, selecting the “volcano-plot outer spray”) has long been equally biologically relevant and statistically troublesome. However, recent proposals are paving the way to resolving this dilemma.
摘要
使用效应大小及其差异状态显著性来选择组学生物标志物（即选择“火山图外部喷溅部分”）长期以来在生物学上同样具有相关性，但在统计学上却很麻烦。然而，最近的提议正在为解决这一困境铺平道路。
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