College of Geography and Environmental Sciences, Key Laboratory of Watershed Earth Surface Processes and Ecological Security, College of Chemistry and Materials Sciences, Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua, 321004, China.
Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China.
Mikrochim Acta. 2024 Feb 16;191(3):139. doi: 10.1007/s00604-024-06230-6.
Bisphenol A (BPA), an important endocrine disrupting compound, has infiltrated human daily lives through electronic devices, food containers, and children's toys. Developing of novel BPA assay methods with high sensitivity holds tremendous importance in valuing the pollution state. Here, we constructed an ultrasensitive photoelectrochemical (PEC) aptasensor for BPA determination by regulating photoactivities of CdS/Ni-based metal-organic framework (CdS/Ni-MOF) with [Ru(bpy)dppz] sensitizer. CdS/Ni-MOF spheres exhibited excellent photocatalytic performance, serving as a potential sensing platform for the construction of target recognition process. [Ru(bpy)dppz] were embedded into DNA double-stranded structure, functioning as sensitizer for modulating the signal response of the developed PEC aptasensor. The proposed PEC sensor exhibited outstanding analytical performances, including a wide linear range (0.1 to 1000.0 nM), low detection limit (0.026 nM, at 3σ/m), excellent selectivity, and high stability. This work provides a perspective for the design of ideal photosensitive materials and signal amplification strategies and extends their application in environment analysis.
双酚 A（BPA）是一种重要的内分泌干扰化合物，通过电子设备、食品容器和儿童玩具渗透到人类的日常生活中。开发具有高灵敏度的新型 BPA 分析方法对于评估污染状况具有重要意义。在这里，我们通过用 [Ru(bpy)dppz] 敏化剂调节 CdS/Ni 基金属-有机骨架（CdS/Ni-MOF）的光活性，构建了用于测定 BPA 的超灵敏光电化学（PEC）适体传感器。CdS/Ni-MOF 球体表现出优异的光催化性能，可用作目标识别过程构建的潜在传感平台。[Ru(bpy)dppz] 嵌入到 DNA 双链结构中，用作敏化剂，用于调节所开发的 PEC 适体传感器的信号响应。所提出的 PEC 传感器表现出出色的分析性能，包括宽线性范围（0.1 至 1000.0 nM）、低检测限（0.026 nM，在 3σ/m 时）、优异的选择性和高稳定性。这项工作为设计理想的光敏材料和信号放大策略提供了新视角，并扩展了它们在环境分析中的应用。
