Moon H W, Fung P Y, Isaacson R E, Booth G D
Infect Immun. 1979 Jul;25(1):127-32. doi: 10.1128/iai.25.1.127-132.1979.
Some interrelationships among age, ambient temperature, intestinal transit, and enterotoxigenic Escherichia coli infection were studied in an infant mouse model. The transit of dye in the small intestine was accelerated during the response to heat-stable E. coli enterotoxin. Transit in the small intestine of normal mice accelerated with increased age (from less than 17 h to 8 days old) and accelerated with increased ambient temperature (from 25 to 37 degrees C). Transit was more rapid in the jejunum than in the ileum throughout the range of experimental conditions studied. E. coli strains that do not produce any of the pili known facilitate intestinal colonization were cleared from the small intestine more rapidly at 37 degrees C than at 25 degrees C. This clearance was thought to be due to accelerated transit at the higher temperature. In contrast, a strain of E. coli that produces K99 (pili previously shown to facilitate intestinal colonization in other species) was not cleared from the small intestine and colonized more intensively at 37 degrees C than at 25 degrees C. Intensified colonization by this strain was thought to be due to increased production of K99 at the higher temperature. It was suggested that sluggish intestinal transit may also be characteristic of the neonates of other species and be one of the factors predisposing them to intestinal colonization by enteropathogens. It was speculated that this predisposition may be enhanced if the neonates are chilled. However, the effect of ambient temperature on intestinal transit in homeothermic neonates such as pigs, calves, and humans may be different from that in mice because neonatal mice are poikilothermic.
在幼鼠模型中研究了年龄、环境温度、肠道转运和产肠毒素大肠杆菌感染之间的一些相互关系。在对热稳定大肠杆菌肠毒素的反应过程中，染料在小肠中的转运加速。正常小鼠小肠中的转运随着年龄增长（从小于17小时到8日龄）而加速，并且随着环境温度升高（从25℃到37℃）而加速。在所研究的整个实验条件范围内，空肠中的转运比回肠更快。不产生任何已知有助于肠道定植的菌毛的大肠杆菌菌株在37℃时比在25℃时从小肠中清除得更快。这种清除被认为是由于较高温度下转运加速所致。相比之下，一株产生K99（先前已证明在其他物种中有助于肠道定植的菌毛）的大肠杆菌菌株未从小肠中清除，并且在37℃时比在25℃时更密集地定植。该菌株定植增强被认为是由于在较高温度下K99产量增加所致。有人提出，肠道转运缓慢也可能是其他物种新生儿的特征，并且是使他们易患肠道病原体肠道定植的因素之一。据推测，如果新生儿受冷，这种易感性可能会增强。然而，环境温度对猪、牛和人类等恒温动物新生儿肠道转运的影响可能与对小鼠的影响不同，因为新生小鼠是变温动物。
