Whipp S C, Moon H W, Lyon N C
Infect Immun. 1975 Aug;12(2):240-4. doi: 10.1128/iai.12.2.240-244.1975.
Hysterectomy-derived, colostrum-deprived piglets were infected with enterotoxigenic Escherichia coli on day 4 of life. Samples of feces and intestinal contents were collected and tested in infant mice for enterotoxic activity. Positive enterotoxic responses were observed in mice given filtrates of feces and intestinal contents from piglets infected withe enterotoxigenic E. coli known to produce heat-stable enterotoxin but not heat-liabile enterotoxin in vitro. It is concluded that heat-stable enterotoxigenic E. coli induce diarrhea by production of heat-stable enterotoxin in vivo.
子宫切除、初乳缺乏的仔猪在出生后第4天感染产肠毒素大肠杆菌。收集粪便和肠内容物样本，并在幼鼠中检测其肠毒素活性。在给予感染产肠毒素大肠杆菌的仔猪粪便和肠内容物滤液的小鼠中观察到阳性肠毒素反应，已知该大肠杆菌在体外产生热稳定肠毒素但不产生不耐热肠毒素。结论是热稳定产肠毒素大肠杆菌在体内通过产生热稳定肠毒素诱导腹泻。
