Department of Dermatology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.
J Dermatol. 2024 Apr;51(4):532-538. doi: 10.1111/1346-8138.17118. Epub 2024 Feb 17.
Primary cutaneous malignancies are among the most commonly diagnosed types of cancer worldwide. We aimed to examine the incidence and 5-year survival rates of all types of primary cutaneous malignancies in the Korean population. Data from the Korean Nationwide Cancer Registry from 1999 to 2019 were analyzed. The crude incidence rates, age-standardized incidence rates, and 5-year relative survival rates of each type of skin cancer were calculated. A total of 89 965 patients were diagnosed with primary cutaneous malignancies, which was a 7-fold increase from 1999 to 2019. The age-standardized incidence rates increased 3.4-fold in basal cell carcinoma (3.7/100 000 person-years), 2.0-fold in squamous cell carcinoma (1.6/100 000 person-years), 12.0-fold in Bowen disease (1.2/100 000 person-years), and 1.8-fold in malignant melanoma (0.7/10 000 person-years) in 2019. Average annual percentage changes in age-standardized incidence rates were statistically significant in basal cell carcinoma (15.8%), Bowen disease (5.8%), squamous cell carcinoma (5.1%), malignant melanoma (1.2%), melanoma in situ (1.1%), dermatofibrosarcoma protuberans (1.2%), mycosis fungoides (0.5%), primary cutaneous CD30+ T-cell proliferations (0.5%), adnexal and skin appendage carcinoma (0.4%), extramammary Paget's disease (0.2%), and Merkel cell carcinoma (0.2%). The 5-year relative survival rates were the highest in basal cell carcinoma (103.3%), followed by dermatofibrosarcoma protuberans (99.7%) and mycosis fungoides (96.6%), and lowest in angiosarcoma (24.7%). The 5-year relative survival rates steadily increased in extramammary Paget's disease (23.6%), cutaneous B-cell lymphoma (21.3%), mycosis fungoides (20.2%), extranodal NK/T-cell lymphoma, nasal type (18.1%), and malignant melanoma (16.1%) from 1996-2000 to 2015-2019. Most primary cutaneous malignancies have increased in incidence and survival rates in the Korean population, but to varying extents depending on the type of skin cancer.
原发性皮肤恶性肿瘤是全球最常见的癌症类型之一。本研究旨在探讨韩国人群中所有原发性皮肤恶性肿瘤的发病率和 5 年生存率。对 1999 年至 2019 年韩国全国癌症登记处的数据进行了分析。计算了每种皮肤癌的粗发病率、年龄标准化发病率和 5 年相对生存率。共有 89965 例患者被诊断为原发性皮肤恶性肿瘤，与 1999 年相比增加了 7 倍。2019 年，基底细胞癌的年龄标准化发病率增加了 3.4 倍（3.7/10 万人口/年），鳞状细胞癌增加了 2.0 倍（1.6/10 万人口/年）， Bowen 病增加了 12.0 倍（1.2/10 万人口/年），恶性黑色素瘤增加了 1.8 倍（0.7/10 000 人口/年）。基底细胞癌（15.8%）、 Bowen 病（5.8%）、鳞状细胞癌（5.1%）、恶性黑色素瘤（1.2%）、原位黑色素瘤（1.1%）、隆突性皮肤纤维肉瘤（1.2%）、蕈样真菌病（0.5%）、原发性皮肤 CD30+T 细胞增生（0.5%）、附属器和皮肤附件癌（0.4%）、乳腺外 Paget 病（0.2%）和 Merkel 细胞癌（0.2%）的年龄标准化发病率的年均变化率具有统计学意义。基底细胞癌的 5 年相对生存率最高（103.3%），其次是隆突性皮肤纤维肉瘤（99.7%）和蕈样真菌病（96.6%），而血管肉瘤的 5 年相对生存率最低（24.7%）。1996-2000 年至 2015-2019 年，乳腺外 Paget 病（23.6%）、皮肤 B 细胞淋巴瘤（21.3%）、蕈样真菌病（20.2%）、结外 NK/T 细胞淋巴瘤，鼻型（18.1%）和恶性黑色素瘤（16.1%）的 5 年相对生存率稳步上升。在韩国人群中，大多数原发性皮肤恶性肿瘤的发病率和生存率都有所上升，但不同类型的皮肤癌上升程度不同。
