Gani Abm Shakil, Al Mahmood Abdullah, Alam Afm Shafiqul, Rahman Mizanur, Alam Raqibul, Mahmud Tasnim
Department of Hepatology, Sheikh Hasina Medical College Hospital, Tangail, Bangladesh.
Euroasian J Hepatogastroenterol. 2024 Jul-Dec;14(2):172-175. doi: 10.5005/jp-journals-10018-1444. Epub 2024 Dec 27.
The strong association between type 2 diabetes mellitus (T2DM) and fatty liver is well known, and its nomenclature has even recently changed to metabolic dysfunction-associated steatotic liver disease (MASLD). Healthy MASLD patients are frequently overlooked and maltreated, especially in Bangladesh. In this present study, we tried to correlate T2DM burden in apparently healthy, incidentally diagnosed fatty liver patients on ultrasound.
This cross-sectional study was done in Sheikh Hasina Medical College Hospital, Tangail, Bangladesh, from August 2022 to February 2023. A total of 92 patients with ultrasonological evidence of grade II fatty change in the liver were included and evaluated. Known T2DM, hypothyroidism, consumption of alcohol, HBV or HCV infection, Wilson's disease, autoimmune liver disease, hemochromatosis, and any other chronic liver or kidney disease patients were excluded. The patients were then assessed for the presence and absence of T2DM using OGTT (2 hours 75 gm glucose ≥ 11.1 mmol/L) and/or HbA1c (≥6.5%) as diagnostic criteria. Data was analyzed by SPSS, version 23.
Out of 92 patients, 48 were male and 44 were female. A total of 50 patients (54.3%) were newly diagnosed with T2DM. Statistically significant differences were seen in the T2DM group and non-DM group for AST (50.33 IU vs 36.53 IU) and TG (270 mg/dL vs 189 mg/dL). Although no noteworthy differences were evident in mean age (41 years vs 38 years), ALT (58.9 IU vs 60.23 IU), and BMI (28.85 vs 29.29).
In the present study, more than 54% of patients with grade II fatty liver were newly diagnosed with T2DM. They would later present with more advanced T2DM and related complications. Although a larger study is needed, physicians and healthcare workers in Bangladesh should be more concerned about treating MASLD patients with early diagnosis of T2DM, recommending prompt lifestyle interventions, and prescribing drugs if necessary.
Gani ABMS, Mahmood AA, Alam AFMS, Higher Incidence of Diabetes in Asymptomatic Healthy Fatty Liver Patients of Bangladesh: Prompt Intervention can Avert Complications. Euroasian J Hepato-Gastroenterol 2024;14(2):172-175.
2型糖尿病（T2DM）与脂肪肝之间的密切关联众所周知，其命名最近甚至已改为代谢功能障碍相关脂肪性肝病（MASLD）。健康的MASLD患者经常被忽视和误诊，尤其是在孟加拉国。在本研究中，我们试图将超声检查偶然诊断出的明显健康的脂肪肝患者的T2DM负担关联起来。
本横断面研究于2022年8月至2023年2月在孟加拉国坦盖尔的谢赫·哈西娜医学院医院进行。共纳入92例肝脏超声显示II级脂肪变的患者并进行评估。排除已知患有T2DM、甲状腺功能减退、饮酒、HBV或HCV感染、威尔逊病、自身免疫性肝病、血色素沉着症以及任何其他慢性肝病或肾病的患者。然后以OGTT（2小时75克葡萄糖≥11.1 mmol/L）和/或糖化血红蛋白（HbA1c，≥6.5%）作为诊断标准，评估患者是否患有T2DM。数据采用SPSS 23版进行分析。
92例患者中，男性48例，女性44例。共有50例患者（54.3%）新诊断为T2DM。T2DM组和非糖尿病组在谷草转氨酶（AST，50.33 IU对36.53 IU）和甘油三酯（TG，270 mg/dL对189 mg/dL）方面存在统计学显著差异。尽管在平均年龄（41岁对38岁）、谷丙转氨酶（ALT）（58.9 IU对60.23 IU）和体重指数（BMI）（28.85对29.29）方面无明显差异。
在本研究中，超过54%的II级脂肪肝患者新诊断为T2DM。他们随后可能会出现更晚期的T2DM及相关并发症。尽管需要进行更大规模的研究，但孟加拉国的医生和医护人员应更加关注对T2DM早期诊断的MASLD患者进行治疗，建议及时进行生活方式干预，并在必要时开药。
Gani ABMS, Mahmood AA, Alam AFMS, 孟加拉国无症状健康脂肪肝患者糖尿病发病率更高：及时干预可避免并发症。《欧亚肝脏胃肠病学杂志》2024；14(2):172 - 175。
