Wang Shihao, Cheng Xiaoyu, Ma Tao, Wang Shasha, Yang Shilong, Zhu Wenyuan, Song Junlong, Han Jingquan, Jin Yongcan, Guo Jiaqi
Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources and International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China.
Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing, 210037, China.
Carbohydr Polym. 2024 Apr 15;330:121822. doi: 10.1016/j.carbpol.2024.121822. Epub 2024 Jan 15.
Hydroxypropyl cellulose (HPC) is a sustainable cellulose derivative valued for its excellent biocompatibility and solubility and is widely used in various fields. Recent scientific research on high-substituted HPC mainly focused on its efficient preparation and phase transition behavior. Herein, a novel strategy of high-substituted HPC synthesis was demonstrated by employing DMSO/TBAF·3HO as a cellulose solvent, exhibiting more efficiency than traditional approaches. High-substituted HPC prepared has remarkable thermal stability, exceptional hydrophilicity, and satisfactory solubility. Phase transition behavior of HPC with varying molar degrees of substitution (MS) was delved and a notable negative correlation between MS and cloud point temperature (T), was revealed, particularly evident at an MS of 12.3, where the T drops to 33 °C. Moreover, a unique self-assembly behavior featuring structural color and responsiveness to force in a solvent-free environment emerged when the MS exceeded 10.4. These insights comprehensively strengthen the understanding and knowledge of high-substituted HPC, simultaneously paving the way for further HPC investigation and exploitation.
羟丙基纤维素（HPC）是一种可持续的纤维素衍生物，因其优异的生物相容性和溶解性而受到重视，并广泛应用于各个领域。近期关于高取代度HPC的科学研究主要集中在其高效制备和相变行为上。在此，通过使用二甲基亚砜/三氟甲磺酸三乙胺·3H₂O作为纤维素溶剂，展示了一种合成高取代度HPC的新策略，该策略比传统方法更高效。所制备的高取代度HPC具有显著的热稳定性、出色的亲水性和令人满意的溶解性。对不同取代度（MS）的HPC的相变行为进行了深入研究，结果表明MS与浊点温度（T）之间存在显著的负相关，在MS为12.3时尤为明显，此时T降至33°C。此外，当MS超过10.4时，在无溶剂环境中出现了一种独特的自组装行为，具有结构色和对力的响应性。这些见解全面加强了对高取代度HPC的理解和认识，同时为进一步研究和开发HPC铺平了道路。
