Kelliher Lisa, Kiely Mairead E, Browne Jillian R-M, O'Callaghan Yvonne C, Hennessy Áine
Cork Centre for Vitamin D & Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Republic of Ireland.
INFANT Research Centre, University College Cork, Cork, Republic of Ireland.
Eur J Nutr. 2025 May 9;64(4):173. doi: 10.1007/s00394-025-03692-z.
Adequate maternal iodine status is essential for healthy foetal brain development. There are no current data on maternal iodine status in Ireland. The aim of this study was to conduct the first large-scale assessment of maternal iodine status in Ireland and identify its sociodemographic determinants using data from a large prospective pregnancy cohort.
Participants were nulliparous females (n = 1509) recruited at Cork University Maternity Hospital, Cork, Ireland. Clinical and questionnaire-based assessments were carried out and spot urine samples were collected throughout pregnancy. Urinary iodine concentration (UIC) at 11 and 15 weeks of gestation was quantified using the Sandell-Kolthoff colorimetric method. UIC was corrected for urinary creatinine (measured via Jaffe assay), expressed as I: Cr ratio. Linear and logistic regression were performed to identify non-dietary determinants of iodine status in early pregnancy.
Median (IQR) UIC at 11 and 15 weeks of gestation were 128 (76, 201) and 125 (74, 208) µg/L, respectively, indicating mild-to-moderate iodine deficiency during pregnancy at both timepoints. Iodine-containing supplement use, winter season, BMI, age and education were predictors of I: Cr < 150 µg/g.
This first large-scale investigation of maternal iodine status in Ireland highlighted sub-optimal status in pregnancy.
充足的母体碘状态对胎儿大脑健康发育至关重要。目前尚无爱尔兰母体碘状态的数据。本研究的目的是对爱尔兰母体碘状态进行首次大规模评估，并利用来自一个大型前瞻性妊娠队列的数据确定其社会人口学决定因素。
参与者为在爱尔兰科克大学妇产医院招募的未生育女性（n = 1509）。在整个孕期进行了临床和基于问卷的评估，并收集了即时尿样。采用桑德尔-科尔托夫比色法对妊娠11周和15周时的尿碘浓度（UIC）进行定量。UIC经尿肌酐校正（通过杰氏法测量），以碘：肌酐比值表示。进行线性和逻辑回归以确定孕早期碘状态的非饮食决定因素。
妊娠11周和15周时UIC的中位数（IQR）分别为128（76，201）和125（74，208）μg/L，表明两个时间点孕期均存在轻度至中度碘缺乏。使用含碘补充剂、冬季、体重指数、年龄和教育程度是碘：肌酐＜150μg/g的预测因素。
爱尔兰首次对母体碘状态进行的大规模调查突出了孕期碘状态不理想的情况。
