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A message from Mr. David Bennett Jr., the son of the first patient to receive a gene-edited pig heart transplant.来自小大卫·班尼特先生的消息，他是首位接受基因编辑猪心脏移植患者的儿子。
Xenotransplantation. 2023 Nov-Dec;30(6):e12839. doi: 10.1111/xen.12839. Epub 2023 Dec 13.
2
Design and testing of a humanized porcine donor for xenotransplantation.用于异种移植的人性化猪供体的设计和测试。
Nature. 2023 Oct;622(7982):393-401. doi: 10.1038/s41586-023-06594-4. Epub 2023 Oct 11.
3
Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.同情性使用基因工程猪-人心脏异种移植中的移植物功能障碍：一例报告。
Lancet. 2023 Jul 29;402(10399):397-410. doi: 10.1016/S0140-6736(23)00775-4. Epub 2023 Jun 29.
4
First transplantation of a pig heart from a multiple gene-modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs.首例来自多基因修饰供体猪的心脏移植、猪巨细胞病毒/玫瑰疹病毒及抗病毒药物
Xenotransplantation. 2023 May-Jun;30(3):e12800. doi: 10.1111/xen.12800. Epub 2023 Apr 11.
5
The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?首例临床猪心脏移植：免疫球蛋白或猪巨细胞病毒对结果有影响吗？
Xenotransplantation. 2022 Jul;29(4):e12771. doi: 10.1111/xen.12771. Epub 2022 Aug 9.
6
The respective relevance of sensitization to alloantigens and xenoantigens in pig organ xenotransplantation.在猪器官异种移植中，同种异体抗原和异种抗原致敏的各自相关性。
Hum Immunol. 2023 Jan;84(1):18-26. doi: 10.1016/j.humimm.2022.06.003. Epub 2022 Jul 8.
7
Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.基因编辑猪-人心脏异种移植。
N Engl J Med. 2022 Jul 7;387(1):35-44. doi: 10.1056/NEJMoa2201422. Epub 2022 Jun 22.
8
Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation.心脏异种移植：临床转化的临床前模型进展与展望。
Transpl Int. 2022 Mar 23;35:10171. doi: 10.3389/ti.2022.10171. eCollection 2022.
9
Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.猪心异种移植物的渐进式遗传修饰将存活时间延长至 9 个月。
Xenotransplantation. 2022 May;29(3):e12744. doi: 10.1111/xen.12744. Epub 2022 Mar 31.
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The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors.异种移植心脏的生长可以通过生长激素受体敲除猪供体来减少。
J Thorac Cardiovasc Surg. 2023 Feb;165(2):e69-e81. doi: 10.1016/j.jtcvs.2021.07.051. Epub 2021 Sep 4.

Clinical Pig Heart Xenotransplantation-Where Do We Go From Here?

作者信息

Cooper David K C, Cozzi Emanuele

机构信息

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Department of Cardiac, Thoracic and Vascular Sciences, Padua University Hospital, Padova, Italy.

出版信息

Transpl Int. 2024 Feb 2;37:12592. doi: 10.3389/ti.2024.12592. eCollection 2024.

DOI:10.3389/ti.2024.12592
PMID:38371908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10869462/
Abstract
摘要