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Clinical Pig Heart Xenotransplantation-Where Do We Go From Here?

作者信息

Cooper David K C, Cozzi Emanuele

机构信息

Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Department of Cardiac, Thoracic and Vascular Sciences, Padua University Hospital, Padova, Italy.

出版信息

Transpl Int. 2024 Feb 2;37:12592. doi: 10.3389/ti.2024.12592. eCollection 2024.

Abstract
摘要

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本文引用的文献

1
A message from Mr. David Bennett Jr., the son of the first patient to receive a gene-edited pig heart transplant.
Xenotransplantation. 2023 Nov-Dec;30(6):e12839. doi: 10.1111/xen.12839. Epub 2023 Dec 13.
2
Design and testing of a humanized porcine donor for xenotransplantation.
Nature. 2023 Oct;622(7982):393-401. doi: 10.1038/s41586-023-06594-4. Epub 2023 Oct 11.
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Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.
Lancet. 2023 Jul 29;402(10399):397-410. doi: 10.1016/S0140-6736(23)00775-4. Epub 2023 Jun 29.
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First transplantation of a pig heart from a multiple gene-modified donor, porcine cytomegalovirus/roseolovirus, and antiviral drugs.
Xenotransplantation. 2023 May-Jun;30(3):e12800. doi: 10.1111/xen.12800. Epub 2023 Apr 11.
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The first clinical pig heart transplant: Was IVIg or pig cytomegalovirus detrimental to the outcome?
Xenotransplantation. 2022 Jul;29(4):e12771. doi: 10.1111/xen.12771. Epub 2022 Aug 9.
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The respective relevance of sensitization to alloantigens and xenoantigens in pig organ xenotransplantation.
Hum Immunol. 2023 Jan;84(1):18-26. doi: 10.1016/j.humimm.2022.06.003. Epub 2022 Jul 8.
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Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.
N Engl J Med. 2022 Jul 7;387(1):35-44. doi: 10.1056/NEJMoa2201422. Epub 2022 Jun 22.
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Cardiac Xenotransplantation: Progress in Preclinical Models and Prospects for Clinical Translation.
Transpl Int. 2022 Mar 23;35:10171. doi: 10.3389/ti.2022.10171. eCollection 2022.
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Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months.
Xenotransplantation. 2022 May;29(3):e12744. doi: 10.1111/xen.12744. Epub 2022 Mar 31.
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The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors.
J Thorac Cardiovasc Surg. 2023 Feb;165(2):e69-e81. doi: 10.1016/j.jtcvs.2021.07.051. Epub 2021 Sep 4.

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