四价人乳头瘤病毒疫苗在不同种族/民族群体中的高影响：2003-2006 年和 2015-2018 年全国健康和营养调查。
High impact of quadrivalent human papillomavirus vaccine across racial/ethnic groups: National Health and Nutrition Examination Survey, 2003-2006 and 2015-2018.
机构信息
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA.
出版信息
Hum Vaccin Immunother. 2024 Dec 31;20(1):2308378. doi: 10.1080/21645515.2024.2308378. Epub 2024 Feb 19.
Human papillomavirus (HPV) causes cervical as well as other cancers. Racial and ethnic disparities in cervical cancer incidence and mortality in the United States are well documented. HPV vaccination has been recommended in the United States since 2006 and is expected to prevent HPV-attributable cancers in all racial/ethnic groups. Quadrivalent HPV vaccine-type (HPV6/11/16/18) and nonvaccine-type cervicovaginal HPV prevalences were estimated from National Health and Nutrition Examination Surveys in 2015-2018 (vaccine era) and 2003-2006 (prevaccine era) data. Prevalence ratios comparing 2015-2018 to 2003-2006 were calculated among sexually experienced Non-Hispanic White (NHW), Non-Hispanic Black (NHB), and Mexican American (MA) females aged 14-24 years. Quadrivalent HPV vaccine-type prevalence declined 82% (CI: 60%-92%) among NHW, 86% (CI: 64%-95%) among NHB, and 100% among MA females, forecasting future reductions in cervical cancer across racial/ethnic groups.
人乳头瘤病毒（HPV）可导致宫颈癌及其他癌症。美国在宫颈癌发病率和死亡率方面存在明显的种族和民族差异，这一点已有充分的文献记载。自 2006 年以来，美国已推荐 HPV 疫苗接种，并预计该疫苗将预防所有种族/民族群体的 HPV 相关癌症。四价 HPV 疫苗型（HPV6/11/16/18）和非疫苗型宫颈阴道 HPV 流行率是根据 2015-2018 年（疫苗时代）和 2003-2006 年（疫苗前时代）的全国健康和营养调查数据估计的。对 14-24 岁有过性行为的非西班牙裔白人（NHW）、非西班牙裔黑人（NHB）和墨西哥裔美国（MA）女性，计算了 2015-2018 年与 2003-2006 年相比的流行率比。四价 HPV 疫苗型的流行率在 NHW 中下降了 82%（CI：60%-92%），在 NHB 中下降了 86%（CI：64%-95%），在 MA 女性中下降了 100%，预计未来各种族/民族群体的宫颈癌发病率将会下降。
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