Institute of Biological Sciences (ISB), Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia.
Biosci Rep. 2024 Mar 29;44(3). doi: 10.1042/BSR20231827.
Septin proteins are a subfamily of closely related GTP-binding proteins conserved in all species except for higher plants and perform essential biological processes. Septins self-assemble into heptameric or octameric complexes and form higher-order structures such as filaments, rings, or gauzes by end-to-end binding. Their close association with cell membrane components makes them central in regulating critical cellular processes. Due to their organisation and properties, septins function as diffusion barriers and are integral in providing scaffolding to support the membrane's curvature and stability of its components. Septins are also involved in vesicle transport and exocytosis through the plasma membrane by co-localising with exocyst protein complexes. Recently, there have been emerging reports of several human and animal diseases linked to septins and abnormalities in their functions. Most of our understanding of the significance of septins during microbial diseases mainly pertains to their roles in bacterial infections but not viruses. This present review focuses on the known roles of septins in host-viral interactions as detailed by various studies.
七蛋白是一个密切相关的 GTP 结合蛋白亚家族，除了高等植物外，在所有物种中都保守存在，执行着重要的生物学过程。七蛋白自我组装成七聚体或八聚体复合物，并通过末端结合形成更高阶的结构，如纤维、环或网。它们与细胞膜成分的密切关联使它们成为调节关键细胞过程的核心。由于其组织和特性，七蛋白作为扩散障碍发挥作用，并为膜的曲率和组成部分的稳定性提供支架。七蛋白还通过与胞吐蛋白复合物共定位参与囊泡运输和胞吐作用穿过质膜。最近，有越来越多的报告表明，几种人类和动物疾病与七蛋白及其功能异常有关。我们对七蛋白在微生物疾病中的重要性的理解主要涉及它们在细菌感染中的作用，但不涉及病毒。本综述重点介绍了各种研究详细阐述的七蛋白在宿主-病毒相互作用中的已知作用。
