Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
College of Public Health, University of South China, Hengyang, 421001, Hunan, China.
J Assist Reprod Genet. 2024 Mar;41(3):767-779. doi: 10.1007/s10815-024-03052-6. Epub 2024 Feb 19.
Coenzyme Q10 (CoQ10) is a natural component widely present in the inner membrane of mitochondria. CoQ10 functions as a key cofactor for adenosine triphosphate (ATP) production and exhibits antioxidant properties in vivo. Mitochondria, as the energy supply center of cells, play a crucial role in germ cell maturation and embryonic development, a complicated process of cell division and cellular differentiation that transforms from a single cell (zygote) to a multicellular organism (fetus). Here, we discuss the effects of CoQ10 on oocyte maturation and the important role of CoQ10 in the growth of various organs during different stages of fetal development. These allowed us to gain a deeper understanding of the pathophysiology of embryonic development and the potential role of CoQ10 in improving fertility quality. They also provide a reference for further developing its application in clinical treatments.
辅酶 Q10（CoQ10）是一种广泛存在于线粒体内膜的天然成分。CoQ10 作为三磷酸腺苷（ATP）产生的关键辅助因子发挥作用，并在体内具有抗氧化特性。线粒体作为细胞的能量供应中心，在精子细胞成熟和胚胎发育中起着至关重要的作用，这是一个复杂的细胞分裂和细胞分化过程，从一个单细胞（受精卵）转变为多细胞生物体（胎儿）。在这里，我们讨论了 CoQ10 对卵母细胞成熟的影响，以及 CoQ10 在胎儿发育的不同阶段各种器官生长中的重要作用。这些使我们能够更深入地了解胚胎发育的病理生理学以及 CoQ10 在提高生育质量方面的潜在作用。它们也为进一步开发其在临床治疗中的应用提供了参考。
