一项评价现场模型中专业涂敷高氟窝沟封闭剂对牙齿酸蚀磨损疗效的临床初步研究。

Centre for Clinical, Oral and Translational Sciences, Faculty of Dentistry, Oral and Clinical Sciences, King's College London, London, SE1 9RT, United Kingdom.

J Dent. 2024 Apr;143:104884. doi: 10.1016/j.jdent.2024.104884. Epub 2024 Feb 17.

OBJECTIVES

The aim for this pilot study was to investigate the effect of a sodium fluoride varnish on step height measured by a profilometer from human enamel worn by healthy volunteers with a novel in situ/ex vivo erosion design.

METHOD

Healthy volunteers aged 18-70 years wore a palatal splint containing 8 human enamel samples and underwent two 3-day treatment periods for 6 h a day with a varnish containing sodium fluoride at 22,600 ppm and the control with the same ingredients but without fluoride. Each splint contained 4 polished and 4 unpolished samples. The interventions were applied to the surface of the enamel samples in randomised order, removed after 6 h, then immersed ex-vivo in 1 %, pH 2.7 citric acid for 2 min, repeated 4 times a day, over 2 days. Measurements of enamel were assessed blindly by microhardness on day 2 and by non-contact laser profilometry on day 3 for the two treatments.

RESULTS

24 volunteers, 2 males and 22 females aged 27-54 years, were screened and recruited. The delta microhardness, from polished samples removed at the end of day 2, for the control and fluoride treatment was 95.7 (22.9) kgf/mm and 123.7 (28.9) kgf/mm, respectively (p < .005). The mean (SD) step height for the control polished enamel surfaces was 3.67 (2.07) µm and for the fluoride varnish was 1.79 (1.01) µm (p < .0005). The control unpolished enamel surfaces had a mean 2.09 (1.53) µm and the fluoride varnish was 2.11 (1.53) µm but no statistical difference was detected.

CONCLUSIONS

The results from this pilot study, utilizing an in-situ model where enamel was exposed to acid over the course of 2 days, demonstrated that a high fluoride varnish containing sodium fluoride at 22,600 ppm prevented erosive wear compared to a control on the polished enamel surfaces.

CLINICAL SIGNIFICANCE

Intra-oral study demonstrated that a high fluoride varnish containing sodium fluoride at 22,600 ppm reduced erosive tooth wear.

目的

本初步研究旨在利用一种新型原位/体外侵蚀设计，调查氟化物漱口水对健康志愿者磨损的人牙釉质表面高度（由轮廓仪测量）的影响。

方法

18-70 岁的健康志愿者佩戴含有 8 个人牙釉质样本的腭夹板，并进行为期 3 天、每天 6 小时的两种处理期，使用含氟化物（氟浓度为 22600ppm）的漱口水和相同成分但不含氟化物的对照物。每个夹板包含 4 个抛光样本和 4 个未抛光样本。干预措施以随机顺序应用于牙釉质样本表面，处理 6 小时后去除，然后在体外每天重复 4 次、每次 2 分钟，浸入 1%、pH 值 2.7 的柠檬酸中，持续 2 天。在第 2 天通过显微硬度和第 3 天通过非接触式激光轮廓测量对两种处理进行盲法评估。

结果

共筛选和招募了 24 名志愿者，其中 2 名男性和 22 名女性，年龄 27-54 岁。从第 2 天结束时去除的抛光样本中获得的对照和氟化物处理的微硬度差值分别为 95.7（22.9）kgf/mm 和 123.7（28.9）kgf/mm（p<.005）。对照抛光牙釉质表面的平均（SD）台阶高度为 3.67（2.07）μm，氟化物牙釉质为 1.79（1.01）μm（p<.0005）。对照未抛光牙釉质表面的平均高度为 2.09（1.53）μm，氟化物牙釉质为 2.11（1.53）μm，但未检测到统计学差异。