Song Haoyang, Guo Chuan, Wu Ye, Liu Yuheng, Kong Qingquan, Wang Yu
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Cell Dev Biol. 2024 Feb 5;12:1286222. doi: 10.3389/fcell.2024.1286222. eCollection 2024.
Intervertebral disc degeneration (IDD) is the main cause of low back pain (LBP), which significantly impacts global wellbeing and contributes to global productivity declines. Conventional treatment approaches, encompassing conservative and surgical interventions, merely serve to postpone the advancement of IDD without offering a fundamental reversal. Consequently, there is an urgent demand for an effective approach to prevent the progression of IDD. Recent investigations focusing on the treatment of IDD utilizing diverse bioactive substances integrated within various biomaterials have exhibited promising outcomes. Various bioactive substances, encompassing conventional small molecule drugs, small molecule nucleic acids, and cell therapies, exhibit distinct capacities for repairing IDD. Additionally, various biological material delivery systems, such as nano micelles, microspheres, and hydrogels, possess diverse biological and release characteristics. Consequently, these diverse materials and drugs hold promise for advancing the treatment of IDD. This article aims to provide a concise overview of the IDD process and investigate the research advancements in biomaterials and bioactive substances for IDD treatment, delving into their mechanisms.
椎间盘退变（IDD）是腰痛（LBP）的主要原因，对全球健康有重大影响，并导致全球生产力下降。包括保守治疗和手术干预在内的传统治疗方法，只是延缓了IDD的进展，而无法实现根本性逆转。因此，迫切需要一种有效的方法来预防IDD的进展。最近针对利用整合在各种生物材料中的多种生物活性物质治疗IDD的研究显示出了有前景的结果。各种生物活性物质，包括传统小分子药物、小分子核酸和细胞疗法，在修复IDD方面具有不同的能力。此外，各种生物材料递送系统，如纳米胶束、微球和水凝胶，具有不同的生物学和释放特性。因此，这些不同的材料和药物有望推动IDD的治疗。本文旨在简要概述IDD过程，并研究用于IDD治疗的生物材料和生物活性物质的研究进展，深入探讨其作用机制。
