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Field recordings of transcranial magnetic stimulation in human brain postmortem models.

作者信息

Quesada Charles, Fauchon Camille, Pommier Benjamin, Bergandi Florian, Peyron Roland, Mertens Patrick, Garcia-Larrea Luis

机构信息

NeuroPain Team, Centre de Recherche en Neurosciences de Lyon (CRNL), Inserm U1028, CNRS UMR5292, UJM & UCBL, Lyon, France.

Physiotherapy Department, Sciences of Rehabilitation Institute (ISTR), University Claude Bernard Lyon 1, Lyon, France.

出版信息

Pain Rep. 2024 Feb 16;9(2):e1134. doi: 10.1097/PR9.0000000000001134. eCollection 2024 Apr.


DOI:10.1097/PR9.0000000000001134
PMID:38375090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10876241/
Abstract

INTRODUCTION: The ability of repetitive transcranial magnetic stimulation (rTMS) to deliver a magnetic field (MF) in deep brain targets is debated and poorly documented. OBJECTIVE: To quantify the decay of MF in the human brain. METHODS: Magnetic field was generated by single pulses of TMS delivered at maximum intensity using a flat or angulated coil. Magnetic field was recorded by a 3D-magnetic probe. Decay was measured in the air using both coils and in the head of 10 postmortem human heads with the flat coil being positioned tangential to the scalp. Magnetic field decay was interpreted as a function of distance to the coil for 6 potential brain targets of noninvasive brain stimulation: the primary motor cortex (M1, mean depth: 28.5 mm), dorsolateral prefrontal cortex (DLPFC: 28 mm), secondary somatosensory cortex (S2: 35.5 mm), posterior and anterior insulae (PI: 38.5 mm; AI: 43.5 mm), and midcingulate cortex (MCC: 57.5 mm). RESULTS: In air, the maximal MF intensities at coil center were 0.88 and 0.77 T for the flat and angulated coils, respectively. The maximal intracranial MF intensity in the cadaver model was 0.34 T, with a ∼50% decay at 15 mm and a ∼75% MF decay at 30 mm. The decay of the MF in air was similar for the flat coil and significantly less attenuated with the angulated coil (a ∼50% decay at 20 mm and a ∼75% MF decay at 45 mm). CONCLUSIONS: Transcranial magnetic stimulation coil MFs decay in brain structures similarly as in air, attenuation with distance being significantly lower with angulated coils. Reaching brain targets deeper than 20 mm such as the insula or Antérior Cingulate Cortex seems feasible only when using angulated coils. The abacus of MF attenuation provided here can be used to adjust modalities of deep brain stimulation with rTMS in future research protocols.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/773c57c0e91b/painreports-9-e1134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/470b7ddcb559/painreports-9-e1134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/b4de42aafb30/painreports-9-e1134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/09c467704b8d/painreports-9-e1134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/773c57c0e91b/painreports-9-e1134-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/470b7ddcb559/painreports-9-e1134-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/b4de42aafb30/painreports-9-e1134-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/09c467704b8d/painreports-9-e1134-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/631f/10876241/773c57c0e91b/painreports-9-e1134-g004.jpg

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本文引用的文献

[1]
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Commun Biol. 2022-9-21

[2]
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Front Neurosci. 2022-8-25

[3]
Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies.

Sensors (Basel). 2022-7-8

[4]
Cortical stimulation for chronic pain: from anecdote to evidence.

Eur J Phys Rehabil Med. 2022-4

[5]
Posterior-superior insular deep transcranial magnetic stimulation alleviates peripheral neuropathic pain - A pilot double-blind, randomized cross-over study.

Neurophysiol Clin. 2021-8

[6]
Sex differences in brain modular organization in chronic pain.

Pain. 2021-4-1

[7]
New procedure of high-frequency repetitive transcranial magnetic stimulation for central neuropathic pain: a placebo-controlled randomized crossover study.

Pain. 2020-4

[8]
Cortical modulation of nociception by galvanic vestibular stimulation: A potential clinical tool?

Brain Stimul. 2019-10-12

[9]
Insular and anterior cingulate cortex deep stimulation for central neuropathic pain: Disassembling the percept of pain.

Neurology. 2019-4-5

[10]
Report of one confirmed generalized seizure and one suspected partial seizure induced by deep continuous theta burst stimulation of the right operculo-insular cortex.

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