Sukmana Bayu Indra, Saleh Raed Obaid, Najim Maryam Abdulrahman, Al-Ghamdi Hasan S, Achmad Harun, Al-Hamdani Mais Mazin, Taher Abbas Ay, Alsalamy Ali, Khaledi Mansoor, Javadi Kasra
Oral Biology, Lambung Mangkurat, Banjarmasin, Indonesia.
Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.
Front Oncol. 2024 Feb 5;14:1319777. doi: 10.3389/fonc.2024.1319777. eCollection 2024.
Oral Squamous Cell Carcinoma (OSCC) is the most common type of head and neck cancer worldwide. Emerging research suggests a strong association between OSCC and the oral microbiota, a diverse community of bacteria, fungi, viruses, and archaea. Pathogenic bacteria, in particular and , have been closely linked to OSCC. Moreover, certain oral fungi, such as , and viruses, like the human papillomavirus, have also been implicated in OSCC. Despite these findings, the precise mechanisms through which the oral microbiota influences OSCC development remain unclear and necessitate further research. This paper provides a comprehensive overview of the oral microbiota and its relationship with OSCC and discusses potential carcinogenic pathways that the oral microbiota may activate or modulate are also discussed.
口腔鳞状细胞癌（OSCC）是全球最常见的头颈癌类型。新出现的研究表明，OSCC与口腔微生物群（一个由细菌、真菌、病毒和古菌组成的多样化群落）之间存在密切关联。特别是某些致病细菌，已与OSCC紧密相连。此外，某些口腔真菌，如白色念珠菌，以及病毒，如人乳头瘤病毒，也与OSCC有关。尽管有这些发现，但口腔微生物群影响OSCC发展的确切机制仍不清楚，需要进一步研究。本文全面概述了口腔微生物群及其与OSCC的关系，并讨论了口腔微生物群可能激活或调节的潜在致癌途径。
