Vakilian Alireza, Khalili Parvin, Jamali Zahra, -Ahmadi Amir Moghadam, Jalali Nazanin, Mohamadi Movahedeh, Pakzadmoghadam Seyed Hamid, Ayoobi Fatemeh
Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Neurology Department, School of Medicine, Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Prev Med Rep. 2024 Jan 22;38:102621. doi: 10.1016/j.pmedr.2024.102621. eCollection 2024 Feb.
Toxic substances can trigger headaches. The prevalence of pesticide use and headaches was high among the population of Rafsanjan.
A cross-sectional study was used to collect data from 9991 adults who participated via sampling people aged 35-70 years old of both genders from the Rafsanjan Cohort Study (RCS) in Iran. Demographic characteristics, habits, chronic primary headache (CPH), and episodic primary headache (EPH) were measured.
The prevalence of CPH and EPH were 7.4 % and 29.9 % respectively. The multivariable model showed the odds of EPH increased significantly by the pesticide exposure on farm OR: 1.16 (1.02-1.34), in yard OR: 1.18 (1.01-1.39), duration of pesticide exposure in yard > median OR: 1.35 (1.06-1.73), at home OR: 1.31 (1.17-1.46), duration of pesticide exposure at home ≤ median OR: 1.24 (1.10-1.40) and > median OR: 1.38 (1.22-1.57). Also, pesticide preparation OR: 1.20 (1.03-1.39), duration of exposure in pesticide preparation ≤ median OR: 1.31 (1.09-1.57), and duration of exposure in managed spraying pesticide > median OR: 1.28 (1.04-1.57) increased odds of EPH. These results showed that the odds of CPH increased in participants using pesticides at home OR: 1.22 (1.02-1.48), duration of pesticide exposure at home > median OR: 1.37 (1.11-1.70), and duration of pesticide exposure in pesticide preparation > median OR: 0.47 (0.27-0.82). The odds of EPH increased with more pesticide exposures (18 %) and duration of pesticide exposure (25 %).
As evidenced by the obtained results, there is a relationship between pesticide exposure and headaches.
有毒物质可引发头痛。在拉夫桑詹人群中，农药使用与头痛的患病率较高。
采用横断面研究，从伊朗拉夫桑詹队列研究（RCS）中抽取9991名年龄在35至70岁的成年人（男女均有）收集数据。测量人口统计学特征、习惯、慢性原发性头痛（CPH）和发作性原发性头痛（EPH）。
CPH和EPH的患病率分别为7.4%和29.9%。多变量模型显示，在农场接触农药使EPH的几率显著增加，比值比（OR）为1.16（1.02 - 1.34）；在院子里接触农药，OR为1.18（1.01 - 1.39）；在院子里接触农药的持续时间>中位数，OR为1.35（1.06 - 1.73）；在家里接触农药，OR为1.31（1.17 - 1.46）；在家里接触农药的持续时间≤中位数，OR为1.24（1.10 - 1.40），>中位数，OR为1.38（1.22 - 1.57）。此外，配制农药，OR为1.20（1.03 - 1.39）；配制农药时的接触持续时间≤中位数，OR为1.31（1.09 - 1.57）；在管理喷洒农药时的接触持续时间>中位数，OR为1.28（1.04 - 1.57），这些情况均增加了EPH的几率。这些结果表明，在家中使用农药的参与者中CPH的几率增加，OR为1.22（1.02 - 1.48）；在家中接触农药的持续时间>中位数，OR为1.37（1.11 - 1.70）；在配制农药时接触农药的持续时间>中位数，OR为0.47（0.27 - 0.82）。EPH的几率随着更多的农药接触（18%）和农药接触持续时间（25%）而增加。
所得结果证明，农药接触与头痛之间存在关联。
