Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
BMC Cardiovasc Disord. 2021 Jan 2;21(1):2. doi: 10.1186/s12872-020-01788-4.
There are differences of opinion about the beneficial or detrimental effects of opium consumption on cardiovascular diseases (CVDs). So, we aimed to study the association between opium use and CVDs.
We used data obtained from the Rafsanjan Cohort Study (RCS), as a part of the prospective epidemiological research studies in IrAN (PERSIAN), with detailed, validated data on opium consumption and some other exposures. A total of 10,000 adults were enrolled in the study. Logistic regression models were used to assess the possible relationships of opium consumption with the prevalence of ischemic heart diseases (IHD) and myocardial infarction (MI).
In this study, 9990 participants in the baseline phase of the Rafsanjan adult cohort study were included according to their completed questionnaire. Among all participants, 870 and 296 individuals were found to suffer from IHD and MI, respectively. Opium consumption was found to be relatively high in the RCS participants, especially in men (men = 2150 and women = 228). Opium use was associated with a higher odds of IHD and MI, with the adjusted odds ratios (95% CI) of 1.51 (1.22-1.86) and 1.79 (1.31-2.45), respectively. Also, dose-response increases were observed with the highest odds ratios in the 4th quartile for MI and IHD (p-values for trend < 0.001). Increased odds were observed for the two main methods of opium consumption, i.e. oral and smoking, but oral administration had higher odds ratio.
Opium consumption is associated with the increased odds of both IHD and MI diseases.
对于鸦片消费对心血管疾病（CVDs）的有益还是有害影响，存在不同意见。因此，我们旨在研究鸦片使用与 CVDs 之间的关联。
我们使用了来自拉夫桑詹队列研究（RCS）的数据，该研究是伊朗前瞻性流行病学研究（PERSIAN）的一部分，该研究有关于鸦片消费和其他一些暴露因素的详细、经过验证的数据。共有 10000 名成年人参与了这项研究。我们使用逻辑回归模型来评估鸦片消费与缺血性心脏病（IHD）和心肌梗死（MI）患病率之间可能存在的关系。
在这项研究中，根据他们完成的问卷，共纳入了拉夫桑詹成人队列研究基线阶段的 9990 名参与者。在所有参与者中，有 870 人和 296 人分别被发现患有 IHD 和 MI。RCS 参与者中的鸦片消费相对较高，尤其是男性（男性为 2150 人，女性为 228 人）。鸦片使用与 IHD 和 MI 的发生风险增加有关，调整后的优势比（95%CI）分别为 1.51（1.22-1.86）和 1.79（1.31-2.45）。此外，还观察到随着 MI 和 IHD 四分位数中最高的比值，剂量-反应呈上升趋势（趋势检验的 P 值<0.001）。观察到两种主要的鸦片使用方法，即口服和吸烟，均与更高的发病风险相关，但口服方式的比值比更高。
鸦片消费与 IHD 和 MI 疾病的发病风险增加有关。
