Nicoll Rachel
Department of Public Health and Clinical Medicine, Umea University, Umea, SE-901 87, Sweden.
Brain Behav Immun Health. 2019 Nov 14;1:100002. doi: 10.1016/j.bbih.2019.100002. eCollection 2020 Jan.
Sickness behavior, induced by pro-inflammatory cytokines in the early stages of an infection, is well known. A case report of three fracture patients, who were not taking analgesic medication, suggests that the initial symptoms experienced, particularly fatigue and mood changes, mirror those of the sickness behavior of infection. A mini-review only found studies investigating one physical, mental or emotional symptom in fracture patients and none drew a parallel with sickness behavior, suggesting that this is a hitherto unrecognised phenomenon which would benefit from further investigation.
由感染早期促炎细胞因子诱导的疾病行为是众所周知的。一份关于三名未服用止痛药物的骨折患者的病例报告表明，他们最初出现的症状，尤其是疲劳和情绪变化，与感染的疾病行为症状相似。一项小型综述仅发现有研究调查骨折患者的一种身体、心理或情绪症状，且没有一项研究将其与疾病行为进行类比，这表明这是一种迄今未被认识的现象，值得进一步研究。
