CNRS, Univ Paris Est Creteil, Univ Gustave Eiffel, UMR 8208, MSME, F-94010 Créteil, France.
Univ Paris Est Creteil, Univ Gustave Eiffel, CNRS, UMR 8208, MSME, F-94010 Créteil, France.
J Mech Behav Biomed Mater. 2024 Apr;152:106465. doi: 10.1016/j.jmbbm.2024.106465. Epub 2024 Feb 16.
In various medical fields, a change of soft tissue stiffness is associated with its physio-pathological evolution. While elastography is extensively employed to assess soft tissue stiffness in vivo, its application requires a complex and expensive technology. The aim of this study is to determine whether an easy-to-use method based on impact analysis can be employed to determine the concentration of agar-based soft tissue mimicking phantoms. Impact analysis was performed on soft tissue mimicking phantoms made of agar gel with a mass concentration ranging from 1% to 5%. An indicator Δt is derived from the temporal variation of the impact force signal between the hammer and a small beam in contact with the sample. The results show a non-linear decrease of Δt as a function of the agar concentration (and thus of the sample stiffness). The value of Δt provides an estimation of the agar concentration with an error of 0.11%. This sensitivity of the impact analysis based method to the agar concentration is of the same order of magnitude than results obtained with elastography techniques. This study opens new paths towards the development of impact analysis for a fast, easy and relatively inexpensive clinical evaluation of soft tissue elastic properties.
在各个医学领域中，软组织硬度的变化与其生理病理演变有关。虽然弹性成像被广泛用于评估活体软组织的硬度，但它的应用需要复杂且昂贵的技术。本研究旨在确定一种基于冲击分析的简单易用的方法是否可用于确定基于琼脂的软组织模拟体的浓度。对质量浓度范围为 1%至 5%的琼脂凝胶制成的软组织模拟体进行冲击分析。冲击分析是利用一个小锤和一个与样品接触的小梁之间的冲击力信号的时间变化来得出一个指标 Δt。结果表明，Δt 随琼脂浓度（即样品硬度）呈非线性下降。Δt 的值可以用 0.11%的误差来估计琼脂的浓度。该方法对琼脂浓度的敏感性与弹性成像技术的结果相当。这项研究为冲击分析的发展开辟了新的道路，可用于快速、简单和相对经济地评估软组织的弹性特性。
