Morodomi Shinri, Ito Kazushi, Maegawa Satoru, Ujihara Yoshihiro, Sugita Shukei, Nakamura Masanori
Department of Electrical and Mechanical Engineering, Graduate School of Engineering, Nagoya Institute of Technology, Aichi, Japan.
PLoS One. 2025 Apr 14;20(4):e0320705. doi: 10.1371/journal.pone.0320705. eCollection 2025.
The mechanical properties of biological tissues are significant biomarkers for diagnosing various diseases. The aim of this study was to develop an empirical formula to estimate Young's modulus from the acoustic impedance measured by scanning acoustic microscopy. Agar, a material with mechanical properties similar to those of biological tissues, was prepared at concentrations ranging from 5% to 20%. The acoustic impedance was measured by scanning acoustic microscopy, and Young's modulus was determined via indentation testing. The results showed that both the acoustic impedance and Young's modulus increased with agar concentration. Theoretical models did not accurately describe the relationship between the acoustic impedance Z and Young's modulus E; however, the empirical formula [Formula: see text] (with E in Pa and Z in Ns/[Formula: see text]) provided a better fit. This formula could potentially be used to estimate Young's modulus for biological tissues, aiding in the realistic analysis of stress fields and understanding the etiology of various diseases.
生物组织的力学性能是诊断各种疾病的重要生物标志物。本研究的目的是建立一个经验公式，根据扫描声学显微镜测量的声阻抗来估算杨氏模量。制备了浓度范围为5%至20%的琼脂，其力学性能与生物组织相似。通过扫描声学显微镜测量声阻抗，并通过压痕试验测定杨氏模量。结果表明，声阻抗和杨氏模量均随琼脂浓度的增加而增加。理论模型未能准确描述声阻抗Z与杨氏模量E之间的关系；然而，经验公式[公式：见正文]（E的单位为Pa，Z的单位为Ns/[公式：见正文]）拟合效果更好。该公式有可能用于估算生物组织的杨氏模量，有助于对应力场进行实际分析，并理解各种疾病的病因。
