中国鲟（Acipenser sinensis）Dmrt 基因家族的全基因组鉴定、系统发育和表达谱分析。
Genome-wide identification, phylogeny and expressional profile of the Dmrt gene family in Chinese sturgeon (Acipenser sinensis).
机构信息
Chinese Sturgeon Research Institute, China Three Gorges Corporation, Yichang, 443100, Hubei, China.
Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Yichang, 443100, Hubei, China.
出版信息
Sci Rep. 2024 Feb 20;14(1):4231. doi: 10.1038/s41598-024-54899-9.
Chinese sturgeon Dmrt gene family was identified and characterized for the first time. A total of 5 putative Dmrt genes were identified. The gene structure, conserved protein domain and the phylogenetic relationship of Dmrt gene family were systematically analyzed. The expressed profile of Chinese sturgeon Dmrt genes in gonad, pituitary and hypothalamus in the male and female were investigated. The results indicated that the accumulation of Dmrt genes was involved in different tissues, and the expression profile also differed among each Dmrt genes. ASDmrt1A, ASDmrt2, ASDmrt3, and ASDmrtA1 were highly expressed in the testis in comparison with other tissue. This result showed that ASDmrt1A, ASDmrt2, ASDmrt3, and ASDmrtA1 played an important role in the development of testicle, and may be useful tool in distinguishing between male and female of Chinese sturgeon. Our study will provide a basis for additional analyses of Chinese sturgeon Dmrt genes. This systematic analysis provided a foundation for further functional characterization of Dmrt genes with an aim of study of Chinese sturgeon Dmrt gene family.
中国鲟鱼 Dmrt 基因家族被首次鉴定和描述。总共鉴定出 5 个假定的 Dmrt 基因。系统分析了 Dmrt 基因家族的基因结构、保守蛋白结构域和系统进化关系。研究了中国鲟鱼 Dmrt 基因在雌雄两性性腺、垂体和下丘脑组织中的表达谱。结果表明，Dmrt 基因的积累涉及不同组织，并且各 Dmrt 基因的表达谱也存在差异。ASDmrt1A、ASDmrt2、ASDmrt3 和 ASDmrtA1 在睾丸中的表达量明显高于其他组织。这一结果表明，ASDmrt1A、ASDmrt2、ASDmrt3 和 ASDmrtA1 在睾丸发育中起重要作用，可能是鉴别中国鲟鱼雌雄的有用工具。本研究为中国鲟鱼 Dmrt 基因的进一步分析提供了基础。本系统分析为进一步研究 Dmrt 基因的功能特征提供了基础，旨在研究中国鲟鱼 Dmrt 基因家族。
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