Buhl L, Dragsholt C, Svendsen P, Hage E, Buhl M R
Cancer Res. 1985 Mar;45(3):1159-62.
A human mesothelioma was heterotransplanted to nude mice, and the urinary excretions of hypoxanthine, xanthine, pseudouridine, orotic acid, 7-methylguanine, and 1-methylhypoxanthine have been followed before and after the tumor transplantation. The compounds were measured by means of isotachophoresis, which has been found a rapid and precise method. The tumor reached maximum size within 30 days, and at this time a significantly increased excretion of pseudouridine and hypoxanthine was observed. Tumor growth was stopped by chemotherapy (vincristine, cyclophosphamide, prednisolone, and Adriamycin), and corresponding to this, a decrease occurred in both pseudouridine and hypoxanthine excretion to normal values.
将人恶性间皮瘤异种移植到裸鼠体内，在肿瘤移植前后对次黄嘌呤、黄嘌呤、假尿嘧啶核苷、乳清酸、7-甲基鸟嘌呤和1-甲基次黄嘌呤的尿排泄情况进行了跟踪研究。这些化合物通过等速电泳法进行测定，该方法已被证明是一种快速且精确的方法。肿瘤在30天内达到最大尺寸，此时观察到假尿嘧啶核苷和次黄嘌呤的排泄量显著增加。化疗（长春新碱、环磷酰胺、泼尼松龙和阿霉素）使肿瘤生长停止，相应地，假尿嘧啶核苷和次黄嘌呤的排泄量均降至正常值。
