Salomatin V V, Efimenko G P, Kamilov F Kh, Lifshits R I
Vopr Med Khim. 1977 Sep-Oct;23(5):642-6.
Excretion and turnover rate of radioactive pseudouridine were studied in intact and burned rats. The thermic injury increased the pseudouridine excretion and lowered the rate of decrease in its specific radioactivity. Relative increase in excretion of pseudouridine was more distinct for the "B" isomer as compared with the isomer "C". The general pattern of dynamics of alterations in pseudouridine turnover after thermic injury corresponded to the patterns of impairments in metabolism of transfer RNA, which were studied previously. But the rate of pseudouridine turnover considerably exceeded the rate of tRNA metabolism either in normal state or in thermic injury.
在完整大鼠和烧伤大鼠中研究了放射性假尿苷的排泄和周转率。热损伤增加了假尿苷的排泄，并降低了其比放射性的下降速率。与“C”异构体相比，“B”异构体的假尿苷排泄相对增加更为明显。热损伤后假尿苷周转率变化的总体动态模式与先前研究的转运RNA代谢损伤模式相对应。但无论是在正常状态还是热损伤状态下，假尿苷的周转速率都大大超过了tRNA的代谢速率。
