Elmi Sabina, Nylandsted Jesper
Danish Cancer Institute , Copenhagen, Denmark.
Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
J Cell Biol. 2025 Jul 7;224(7). doi: 10.1083/jcb.202505027. Epub 2025 Jun 18.
In this issue, Williams et al. (https://doi.org/10.1083/jcb.202408159) reveal a two-step plasma membrane repair process upon injury: annexins first stabilize damage sites, then calcium-activated calpains cleave these patches, triggering microvesicle shedding-mirroring the clot-and-scab resolution seen in tissue-level wound healing.