Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Emergency, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Microbiol Spectr. 2024 Apr 2;12(4):e0314223. doi: 10.1128/spectrum.03142-23. Epub 2024 Feb 22.
Previous studies have shown that the gut microbiota and its metabolites are associated with the success of organ transplantation. However, the specific changes in the gut microbiota of lung transplant patients remain unclear. Hence, this study aimed to elucidate the interplay between the gut microbiota, metabolome, and lung transplantation outcomes. Using 16S metagenomics sequencing and untargeted metabolic profiling, we conducted a comprehensive analysis of gut microbial and metabolic alterations in lung transplant recipients relative to non-transplant group. Our findings revealed the predominance of and genera within the lung transplant cohort, accompanied by the significant reduction in , , , and abundance. In addition, a significant reduction in ATRA (all-trans retinoic acid) levels and suppression of IgA production were observed in lung transplant recipients, which were found to be closely associated with the genus. It was speculated that the association might have implications for the prognosis of lung transplant patients. Notably, the differences in gut microbial composition and metabolomic profiles between successful transplant recipients and those experiencing chronic rejection were not statistically significant. These novel insights shed light on the putative implications of the gut microbiota and metabolome in shaping lung transplantation outcomes, and provide a foundation for future investigations and targeted therapeutic interventions.
This study has profound implications for lung transplantation as it uncovers the important role of gut microbiota and metabolome in shaping transplantation outcomes. The identification of dominant bacterial genera, such as and , within the lung transplant cohort, along with the significant decrease in , , , and abundance, reveals potential microbial imbalances associated with lung transplantation. In addition, a significant reduction in ATRA (all-trans retinoic acid) levels and suppression of IgA production were observed in lung transplant recipients, which were found to be closely associated with the genus. It was speculated that the association might have implications for the prognosis of lung transplant patients. These findings hold immense clinical significance as they lay the groundwork for future research and targeted therapeutic interventions. Understanding the impact of the gut microbiota and metabolome on lung transplantation outcomes offers promising avenues for improving transplantation patient prognosis.
先前的研究表明，肠道微生物群及其代谢物与器官移植的成功有关。然而，肺移植患者肠道微生物群的具体变化仍不清楚。因此，本研究旨在阐明肠道微生物群、代谢组和肺移植结果之间的相互作用。使用 16S 宏基因组测序和非靶向代谢组学分析，我们对肺移植受者与非移植组的肠道微生物和代谢变化进行了全面分析。我们的研究结果表明，在肺移植队列中， 和 属占优势， 、 、 和 的丰度显著降低。此外，在肺移植受者中观察到 ATRA（全反式视黄酸）水平显著降低和 IgA 产生受到抑制，这与 属密切相关。据推测，这种关联可能对肺移植患者的预后有影响。值得注意的是，成功移植受者和发生慢性排斥反应受者之间的肠道微生物组成和代谢谱差异没有统计学意义。这些新的发现揭示了肠道微生物群和代谢组在塑造肺移植结果方面的潜在意义，并为未来的研究和靶向治疗干预提供了基础。
这项研究对肺移植具有深远的意义，因为它揭示了肠道微生物群和代谢组在塑造移植结果方面的重要作用。在肺移植队列中， 和 等属占优势， 、 、 和 的丰度显著降低，这表明与肺移植相关的潜在微生物失衡。此外，在肺移植受者中观察到 ATRA（全反式视黄酸）水平显著降低和 IgA 产生受到抑制，这与 属密切相关。据推测，这种关联可能对肺移植患者的预后有影响。这些发现具有重要的临床意义，为未来的研究和靶向治疗干预奠定了基础。了解肠道微生物群和代谢组对肺移植结果的影响为改善移植患者的预后提供了有前途的途径。
