钌催化芳香酸与卤代苯胺的C-H芳基化反应合成菲啶酮类化合物
Ruthenium-Catalyzed C-H Arylation of Aromatic Acids with -Haloaniline To Access Phenanthridinones.
作者信息
Luo Xianglin, Shen Jiayi, Jiang Huanfeng, Huang Liangbin
机构信息
State Key Laboratory of Pulp and Paper Engineering, Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
出版信息
Org Lett. 2024 Apr 12;26(14):2883-2887. doi: 10.1021/acs.orglett.3c04377. Epub 2024 Feb 22.
Phenanthridinone is a significant moiety in pharmaceutical and material science; thus, it is highly desirable to develop an efficient and robust method to construct phenanthridinone from readily available starting materials. Herein, we report a Ru-catalyzed C-H arylation of aromatic carboxylic acids with -haloanilines, followed by intramolecular dehydration to afford phenanthridinones in high yields.
菲啶酮是药物和材料科学中的一个重要部分；因此，非常有必要开发一种高效且可靠的方法，从容易获得的起始原料构建菲啶酮。在此，我们报道了一种钌催化的芳族羧酸与卤代苯胺的C-H芳基化反应，随后进行分子内脱水，以高产率得到菲啶酮。
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