Schettini F, De Mattia D, Altomare M, Montagna O, Ciavarella G, Manzionna M M
Acta Paediatr Scand. 1985 Mar;74(2):226-9. doi: 10.1111/j.1651-2227.1985.tb10954.x.
The purpose of this study was to determine the concentration of Protein C in the blood of full-term healthy newborns. The levels of Protein C, evaluated by electroimmunoassay, were low in the first 5 days of life and lower than the critical adult thrombotic level. The antigenic activity increased progressively from the 2nd week of life and the adult values were reached after the 6th month. The reduction of Protein C levels may impair the ability of the newborn to control consumptive disorders, thus exposing the infants to the risk of thrombotic conditions in neonatal age.
本研究的目的是测定足月健康新生儿血液中蛋白C的浓度。通过免疫电泳法评估，蛋白C水平在出生后的前5天较低，低于成人血栓形成的临界水平。抗原活性从出生后第2周开始逐渐增加，6个月后达到成人水平。蛋白C水平的降低可能会损害新生儿控制消耗性疾病的能力，从而使婴儿在新生儿期面临血栓形成的风险。
