Department of Stomatology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Stem Cell Rev Rep. 2024 May;20(4):980-995. doi: 10.1007/s12015-024-10690-x. Epub 2024 Feb 22.
Stem cell therapy for periodontal defects has shown good promise in preclinical studies. The purpose of this study was to evaluate the impact of stem cell support on the regeneration of both soft and hard tissues in periodontal treatment. PubMed, Cochrane Library, Embase, and Web of Science were searched and patients with periodontal defects who received stem cell therapy were included in this study. The quality of the included articles was assessed using Cochrane's tool for evaluating bias, and heterogeneity was analyzed using the I method. An Mendelian randomization investigation was conducted using abstract data from the IEU public databases obtained through GWAS. Nine articles were included for the meta-analysis. Stem cell therapy effectively rebuilds periodontal tissues in patients with periodontal defects, as evidenced by a reduction in probing depth, clinical attachment level and bone defect depth . And delta-like homolog 1 is a protective factor against periodontal defects alternative indicator of tooth loosening. The findings of this research endorse the utilization of stem cell treatment for repairing periodontal defects in individuals suffering from periodontitis. It is recommended that additional extensive clinical investigations be carried out to validate the efficacy of stem cell therapy and encourage its widespread adoption.
干细胞疗法治疗牙周缺损在临床前研究中显示出良好的前景。本研究旨在评估干细胞支持对牙周治疗中软硬组织再生的影响。检索了 PubMed、Cochrane Library、Embase 和 Web of Science，并纳入了接受干细胞治疗的牙周缺损患者。使用 Cochrane 偏倚评估工具评估纳入文章的质量，并使用 I 方法分析异质性。使用通过 GWAS 从 IEU 公共数据库获得的抽象数据进行孟德尔随机化研究。进行了 9 项荟萃分析。干细胞疗法可有效重建牙周缺损患者的牙周组织，表现为探诊深度、临床附着水平和骨缺损深度降低。并且 delta-like 同源物 1 是牙周缺损的保护因子，也是牙齿松动的替代指标。这项研究的结果支持使用干细胞治疗来修复患有牙周炎的个体的牙周缺损。建议进行更多广泛的临床研究来验证干细胞治疗的疗效，并鼓励其广泛应用。
