Nigam S, Becker R, Rosendahl U, Hammerstein J, Benedetto C, Barbero M, Slater T F
Prostaglandins. 1985 Apr;29(4):513-28. doi: 10.1016/0090-6980(85)90076-0.
Peripheral plasma concentrations of 6-keto-PGF1 alpha and TXB2 were measured in patients with benign and malignant tumours of the breast, in patients with non-gynecological diseases, and in healthy female controls. The values were significantly higher in female patients with malignant tumours of the breast than in healthy controls (146 +/- 28 vs 13 +/- 2.5 pg/ml for 6-keto-PGF1 alpha p less than 0.01 and 78 +/- 17 vs 11 +/- 2 pg/ml for TXB2, p less than 0.01). Benign tumours of the breast were also associated with significantly raised plasma levels of 6-keto-PGF1 alpha and TXB2 compared to normal controls (52 +/- 5 vs 13 +/- 2.5 pg/ml for 6-keto-PGF1 alpha, p less than 0.01 and 26 +/- 5 vs 11 +/- 2 pg/ml for TXB2, p less than 0.05). The high levels of 6-keto-PGF1 alpha and TXB2 were not found to be correlated with clinical and histopathological data. The surgical removal of the primary tumour has apparently no effect on the plasma concentrations of 6-keto-PGF1 alpha and TXB2 over a follow-up period of 9 days after operation. The lack of alterations in the ratio of TXB2:6-keto-PGF1 alpha in the cancer patients and other subjects studied before and after surgery is indicative of the regulatory power of metabolic systems to preserve the homeostatic balance.
在患有乳腺良性和恶性肿瘤的患者、患有非妇科疾病的患者以及健康女性对照组中，测量了外周血浆中6-酮-前列环素F1α（6-keto-PGF1 alpha）和血栓素B2（TXB2）的浓度。患有乳腺恶性肿瘤的女性患者的值显著高于健康对照组（6-酮-前列环素F1α为146±28 vs 13±2.5 pg/ml，p<0.01；血栓素B2为78±17 vs 11±2 pg/ml，p<0.01）。与正常对照组相比，乳腺良性肿瘤也与血浆中6-酮-前列环素F1α和血栓素B2水平的显著升高有关（6-酮-前列环素F1α为52±5 vs 13±2.5 pg/ml，p<0.01；血栓素B2为26±5 vs 11±2 pg/ml，p<0.05）。未发现6-酮-前列环素F1α和血栓素B2的高水平与临床和组织病理学数据相关。在手术后9天的随访期内，原发性肿瘤的手术切除显然对6-酮-前列环素F1α和血栓素B2的血浆浓度没有影响。癌症患者和其他研究对象在手术前后TXB2:6-酮-前列环素F1α比值缺乏变化，表明代谢系统具有维持体内平衡的调节能力。
