Li Xueqing, Niu Huixia, Huang Zhengliang, Zhang Man, Xing Mingluan, Chen Zhijian, Wu Lizhi, Xu Peiwei
Zhejiang Provincial Center for Disease Control and Prevention, 3399 Bin Sheng Rd., Binjiang District, Hangzhou 310051, China.
Disease Prevention and Control Center of Jingning She Autonomous County, Lishui 323500, China.
Metabolites. 2024 Feb 6;14(2):108. doi: 10.3390/metabo14020108.
Emerging pollutants, a category of compounds currently not regulated or inadequately regulated by law, have recently become a focal point of research due to their potential toxic effects on human health. The gut microbiota plays a pivotal role in human health; it is particularly susceptible to disruption and alteration upon exposure to a range of toxic environmental chemicals, including emerging contaminants. The disturbance of the gut microbiome caused by environmental pollutants may represent a mechanism through which environmental chemicals exert their toxic effects, a mechanism that is garnering increasing attention. However, the discussion on the toxic link between emerging pollutants and glucose metabolism remains insufficiently explored. This review aims to establish a connection between emerging pollutants and glucose metabolism through the gut microbiota, delving into the toxic impacts of these pollutants on glucose metabolism and the potential role played by the gut microbiota.
新兴污染物是一类目前未受法律监管或监管不足的化合物，由于其对人类健康的潜在毒性作用，最近已成为研究的焦点。肠道微生物群在人类健康中起着关键作用；它特别容易受到一系列有毒环境化学物质（包括新兴污染物）的干扰和改变。环境污染物引起的肠道微生物群紊乱可能是环境化学物质发挥其毒性作用的一种机制，这一机制正受到越来越多的关注。然而，关于新兴污染物与葡萄糖代谢之间的毒性联系的讨论仍未得到充分探索。本综述旨在通过肠道微生物群建立新兴污染物与葡萄糖代谢之间的联系，深入探讨这些污染物对葡萄糖代谢的毒性影响以及肠道微生物群所起的潜在作用。
